Sodium DNA hmoov

PDRN, INCI rau DNA sodium, yog ib qho kev sib xyaw ntawm cov nquag polynucleotides nrog qhov hnyav molecular ntau ntawm 50 ~ 1500 kDa. Tam sim no qhov chaw ntawm extraction thiab purification muaj xws li tib neeg placenta, liab algae, ginseng, thiab phev hlwb ntawm salmon (golden trout) los yog salmon (salmon).

PDRN muaj 50% ob npaug -stranded deoxyribonucleotides, thiab ob lub polydeoxyribonucleotides txuas nrog hydrogen bonds ntawm lub hauv paus khub [adenine (A)=thymine (T); guanine (G)=cytosine (C)], nws thiaj li tsim tau ob lub helix qauv (raws li qhia hauv daim duab 1).

Lub hauv paus muaj pes tsawg leeg ntawm PDRN zoo ib yam li 98% rau tib neeg DNA. Raws li cov txiaj ntsig lom neeg no, nws qhov kev siv tshuaj kho mob tau maj mam nthuav dav, thiab nws tau pom cov txiaj ntsig tseem ceeb hauv kev kho cov ntaub so ntswg, kho qhov txhab, tiv thaiv - ischemia, thiab tiv thaiv - mob.

YTBIO muaj ob hom PDRN cov khoom lag luam: ntses salmon- muab tau thiab sawv- tau los.

• Salmon- muab tau los ntawm PDRN (Cosmetic/Food Grade, 99% Purity)

Ua los ntawm cov qog nqaij hlav qog nqaij hlav los ntawm lub hom phiaj enzymatic hydrolysis thiab ntau -theem purification txheej txheem, ua tiav qhov purity Ntau dua lossis sib npaug li 99%. Nws tuaj yeem siv dav hauv cov khoom siv tu tawv nqaij, kev hnav khaub ncaws kho mob, thiab cov khoom xyaw ntawm qhov ncauj.

• Rose- muab tau los ntawm PDRN (Kev daws teeb meem, 5000ppm, Molecular Luj 50,000-100,000 Da)

Extracted siv cov nroj tsuag kab lis kev cai los yog fermentation technology, nws yog ib tug ntshiab mus rau me ntsis turbid kua nrog ib tug active concentration ntawm 5000ppm thiab ib tug molecular hnyav ntau ntawm 5,000-100,000 Da. Nws khaws cov bioactivity thiab tsim nyog rau vegan formulations, huv si - daim ntawv lo cov khoom tu tawv nqaij, thiab siab - cov khoom kho cov nroj tsuag.

 

Daim ntawv xeem

 

 

Molecular Luj: 650 kDa	Molecular Luj: 1000 kDa

 

Cov txheej txheem ntawm kev ua ntawm PDRN tuaj yeem muab faib ua ob yam:

 

Ua ntej, nws koom nrog "txoj kev cawm seej" los muab cov ntaub ntawv raw rau cell DNA synthesis;

Thib ob, raws li tus agonist ntawm adenosine receptor 2 (A2A), nws koom nrog kev ua kom lossis inhibition ntawm ntau txoj hauv kev, tswj cov khoom lag luam hauv qab thiab siv ntau yam tshuaj. Lub mechanism ntawm kev txiav txim ntawm PDRN yog qhia nyob rau hauv daim duab 2.

1. Txoj kev khaws cia tseem hu ua "txoj kev cawm seej", uas yog, PDRN tuaj yeem muab purine thiab pyrimidine tom qab enzymatic hydrolysis los txhawb kev loj hlob ntawm tes; txoj kev khaws cia tuaj yeem rov ua dua cov hauv paus thiab nucleosides uas tsim los ntawm kev puas tsuaj ntawm DNA thiab RNA, thiab cov hauv paus rov qab tuaj yeem hloov mus rau hauv nucleotides thiab rov ua dua - ua ke rau hauv DNA. Cov nucleotides thiab nucleosides uas tsim los ntawm PDRN tuaj yeem pab sai sai rau DNA tiam thiab muab cov ntaub ntawv raw rau cov ntaub so ntswg rov tsim dua tshiab thiab kho kev puas tsuaj.

2. Adenosine receptor 2 (A2A) agonist A2A receptor belongs rau G protein-coupled receptor, uas tuaj yeem txhawb nqa adenylate cyclase (AC), tswj cov qib cyclic adenosine monophosphate (cAMP), thiab tom qab ntawd qhib cov txheej txheem qhia txog kev sib raug zoo, thiab koom nrog cov txheej txheem inflammatory ntawm tes, txhawb kev tiv thaiv kab mob, tiv thaiv kab mob thiab tiv thaiv kab mob. tswj lub cev tiv thaiv kab mob.

① PDRN activates adenosine A2A receptors, inhibits kev ua haujlwm ntawm nuclear factor-κB (NF-κB) kev taw qhia txoj hauv kev, thiab txo cov kev qhia ntawm pro- cov cim kab mob xws li qog necrosis factor (TNF- ) thiab antileukin 6 IL {-;

② PDRN stimulates A2A receptors, induces intracellular cAMP activation, txhawb cov protein kinase A (PKA) thiab cyclic adenosine monophosphate teb cov ntsiab lus binding protein (CREB) phosphorylation, upregulates anti-apoptosis ntsig txog cov proteins, inhibits apoptosis protein4}{1} (1}) thiab lwm yam cysteine-muaj aspartate PDRN tuaj yeem cuam tshuam qhov kev qhia ntawm Caspase-3 thiab Caspase-9 los ntawm kev ua kom A2A receptors, yog li ua lub luag haujlwm tiv thaiv apoptotic;

③PDRN tuaj yeem txhawb kev tso tawm ntawm vascular endothelial kev loj hlob (VEGF, tshwj xeeb vascular endothelial cell loj hlob yam tseem ceeb uas tuaj yeem txhawb kev kho qhov txhab thiab kho cov ntaub so ntswg), yog li txhim kho angiogenesis thiab txhim kho microcirculation;

Daim duab 3 A2A receptor activation

④PDRN tuaj yeem cuam tshuam kev ua haujlwm ntawm MAPK txoj hauv kev los ntawm kev txhawb nqa A2A receptors, inhibit qhov kev qhia ntawm MMP thiab inflammatory yam, thiab ua lub luag haujlwm zoo hauv kev tsim cov tawv nqaij.

① 700 KDa thiab saum toj no yog siv rau kev tsim kho ntawm daim tawv nqaij, kev sib koom ua ke pob txha mos thiab txhim kho pob txha;

② 350 ~ 500 KDa yog siv rau hauv kev kho tshuaj kom ua tiav cov ntaub so ntswg rov tsim dua tshiab, kho pob txha thiab kho cov kab mob musculoskeletal;

③ 40 ~ 60 KDa yog siv rau hauv cov tshuaj pleev ib ce thiab cov khoom noj kom ua tiav kev kho qhov teeb meem, kev txhim kho wrinkles thiab kev zoo nkauj ntawm daim tawv nqaij.

Cov ntsiab lus: PDRN tuaj yeem tsim cov nucleotides thiab nucleosides uas ua kom DNA synthesis, txhim kho fibroblast proliferation thiab loj hlob muaj peev xwm, vascular endothelial kev loj hlob zoo tshaj plaws qhia, txhawb angiogenesis, txhim kho microcirculation, thiab muab khoom noj khoom haus rau daim tawv nqaij regeneration; inhibit qhov kev qhia ntawm inflammatory cytokines thiab apoptotic proteins, thiab ua kom muaj zog tiv thaiv -cov nyhuv inflammatory; Tsis tas li ntawd, PDRN tuaj yeem tiv thaiv cov ntaub so ntswg los ntawm UV-induced DNA puas.

Cim npe nrov: Tuam Tshoj sodium dna hmoov manufacturers, lwm tus neeg, Hoobkas