Glycyrrhizic acid yog dab tsi?

Glycyrrhizic acid hmoov yog muab los ntawm cov hauv paus hniav thiab rhizomes ntawm licorice, ib tsob nroj leguminous, thiab yog cov khoom xyaw tseem ceeb hauv licorice, nrog rau cov ntsiab lus txog li 10 feem pua. Glycyrrhizic acid, tseem hu ua glycyrrhizin thiab glycyrrhizin, yog glycoside tsim los ntawm glycyrrhetinic acid thiab 2 molecules ntawm glucuronic acid. Dawb rau lub teeb daj crystalline hmoov, tsis muaj ntxhiab, nrog rau ib qho qab zib, qhov qab zib yog li 200 npaug ntawm sucrose. Nws cov qab zib txawv ntawm cov khoom qab zib xws li sucrose. Nws yuav siv sij hawm ib ntus kom muaj qab zib qab zib tom qab nkag, tab sis nws kav ntev. Ib qho me me ntawm liquiritin thiab sucrose tuaj yeem siv 20 feem pua tsawg dua sucrose yam tsis hloov qhov qab zib. Txawm hais tias nws tsis muaj tshuaj tsw qab, nws muaj cov tshuaj tsw qab-txhim kho cov nyhuv. Cov tshuaj aqueous yog qaug zog acidic, thiab pH tus nqi ntawm 2 feem pua tshuaj yog 2.5 ~ 3.5. Insoluble hauv dej, dilute ethanol. Soluble nyob rau hauv dej kub, nws ua viscous jelly tom qab txias. Glycyrrhizic acid yog triterpene saponin. Tsis tas li ntawd, muaj liquiritin, isoliquiritin thiab lwm yam. Glycyrrhiza sp., ib tsob nroj leguminous, yog ib qho tseem ceeb tshuaj suav tshuaj. Nws yog siv nyob rau hauv 74 ntawm 110 tshuaj nyob rau hauv "Treatise on Febrile Diseases". Nws yog muab rho tawm los ntawm licorice thiab muaj ib tug tshwj xeeb qab zib saj. Nws yog tsuas yog siv nyob rau hauv cov zaub mov, thiab nws kuj yog siv nyob rau hauv lwm yam lag luam xws li tshuaj, tshuaj pleev ib ce thiab luam yeeb. Vim tias glycyrrhizic acid feem ntau nrog pseudoaldosteronism hauv kev kho mob daim ntawv thov, cov kws tshaj lij tau ua ntau cov tshuaj synthesis thiab kev hloov kho ntawm nws, thiab glycyrrhizic acid derivatives muaj ntau yam kev siv tshuaj kho mob.

Product Details List

CAS	1405-86-3
Cov mis mos molecular	C42H62O16
Molecular hnyav	822.94
EINECS	215-785-7
Melting point	220 degree (kwv yees kwv yees)
Boiling point	Boiling point
Kev sib hloov tshwj xeeb	D17 ntxiv rau 46.2 degree (c=1.5inalc)
Qhov ntom	1.1442 (zeeg)
Refractive Index	61 degree (C=1.5, EtOH)
Acidity coefficient (pKa)	2.76 ± 0.70 (Kev kwv yees)
Dej solubility	tsis yooj yim soluble hauv dej txias, yooj yim soluble hauv dej kub
Flash point (degree)	288

Cov txiaj ntsig yog dab tsi?

anti-inflammatory
Glycyrrhizic acid hmoov muaj qhov pom tseeb los tiv thaiv kev mob, uas tuaj yeem cuam tshuam cov theem metabolic ntawm phospholipase A2 / arachidonic acid (PLA2 / AA), NF-κB thiab MAPK / AP-1 cov lus teb tseem ceeb ntawm cov teeb meem tshwm sim los ntawm inflammatory stimuli hauv thawj theem, inhibit qhov kev ua ntawm inflammatory teb teeb liab hais txog peb inflammatory pathways, down-regulate lub upstream ntsig txog pro-inflammatory cytokines ntawm inflammatory pathways, xws li TNF-, IL-8, IL-1 , IIL-6, hais txog cov tshuaj chemokines thiab cyclooxygenase (COX) qhia, thaiv cov kab mob hauv qab dej, suav nrog nitric oxide (NO), prostaglandin (PG) thiab reactive oxygen hom (ROS) tiam.
tiv thaiv oxidation
Nws tuaj yeem txhawb kev tsim cov Ⅱ enzymes thiab antioxidant enzymes. Cov qub feem ntau detoxifies thiab excretes carcinogens thiab co toxins. Lub tom kawg tswj qhov sib npaug ntawm cov dawb radicals / oxidants thiab antioxidants nyob rau hauv ib puag ncig intracellular.
Antiviral
Muaj rau cov kauj ruam nyob rau hauv cov txheej txheem replication ntawm feem ntau cov kab mob, xws li adsorption, ntxeem tau, uncoating, biosynthesis, sib dhos thiab tso tawm. Ntawm lawv, adsorption yog tus yuam sij los txiav txim siab qhov ua tiav ntawm kev kis kab mob thiab tseem yog qhov tseem ceeb ntawm nws qhov tshwj xeeb. Adsorption ntawm cov kab mob mus rau lub hlwb yuav tsum tau hais tias cov adsorption proteins ntawm tus kab mob nto tshwj xeeb tshaj yog txuam nrog cell nto receptors. Qhov no zoo li qhov chaw nres nkoj ntawm lub dav hlau thiab chaw nres tsheb, yuav tsum muaj qhov sib txuam. Cov ntaub ntawv yav dhau los tau qhia tias tus kab mob tshiab coronavirus 2019-nCoV ua tiav cov adsorption tshwj xeeb los ntawm kev sib cuam tshuam ntawm nws cov protein ntau thiab tib neeg ACE2 protein.

Glycyrrhizic acid tuaj yeem tsis tsuas yog inhibit tus kab mob replication, tab sis kuj inhibit tus kab mob adsorption thiab membrane nkag mus rau theem pib ntawm tus kab mob replication, thiab nyob rau tib lub sij hawm cuam tshuam tus kab mob DNA thiab RNA replication, yog li inhibiting tus kab mob proliferation thiab tiv thaiv hlwb los ntawm tus kab mob puas lub luag hauj lwm.
Kev tiv thaiv daim siab
Cov kev tshawb fawb tau pom tias glycyrrhizic acid kuj nthuav tawm cov kev ua haujlwm hepatoprotective zoo hauv qee tus tsiaj kab mob siab. Hauv lipopolysaccharide (LPS) thiab D-galactosamine (GalN) ua rau lub siab raug mob, glycyrrhizic acid muaj peev xwm ua kom tag nrho inhibit IL18-induced ALT nce. Glycyrrhizin tuaj yeem txo cov kab mob siab microcirculation-vim lub siab raug mob (histology, daim siab enzymes) thiab txo cov hepatocyte apoptosis los ntawm kev txo qis microcirculation hloov thiab tiv thaiv kev cuam tshuam ntawm endothelin. Nws cov nyhuv hepatoprotective.

Anti-ulcer nyhuv:Glycyrrhizic acid muaj kev tiv thaiv kab mob ntawm lub plab zom mov. Nws tuaj yeem ua kom cov kua qaub tso tawm ntawm lub plab hnyuv mucosa, tsim kev tiv thaiv kev tiv thaiv, thiab txo qis kev puas tsuaj ntawm cov kua qaub rau hauv lub plab. Tsis tas li ntawd, glycyrrhizic acid tseem tuaj yeem cuam tshuam kev loj hlob ntawm Helicobacter pylori thiab txhim kho cov tsos mob ntawm cov kab mob plab los ntawm kab mob plab. Yog li, glycyrrhizic acid feem ntau yog siv los kho cov kab mob hauv plab zom mov xws li gastric ulcer thiab duodenal ulcer.

Anti-allergic nyhuv:Glycyrrhizic acid muaj anti-allergic nyhuv. Nws inhibits qhov tso tawm ntawm histamine, txo cov nqaij o thiab khaus los ntawm kev tsis haum tshuaj. Tsis tas li ntawd, glycyrrhizic acid kuj tuaj yeem tswj hwm qhov sib npaug ntawm lub cev tiv thaiv kab mob thiab txo qhov hnyav ntawm kev tsis haum tshuaj. Yog li ntawd, glycyrrhizic acid feem ntau yog siv rau hauv cov tshuaj suav tshuaj los txo cov kev tsis haum rhinitis, urticaria thiab lwm yam kab mob ua xua.

Txo cov ntshav siab:Glycyrrhizic acid muaj qee yam cuam tshuam rau txo cov ntshav siab. Nws thaiv cov synthesis thiab tso tawm ntawm adrenaline (ib yam khoom uas nce ntshav siab), tswj cov hlab ntsha, thiab txo cov ntshav siab. Yog li ntawd, glycyrrhizic acid feem ntau yog siv nyob rau hauv cov tshuaj suav tshuaj los kho mob ntshav siab thiab kab mob plawv.

Dab tsi yog Daim Ntawv Qhia Cov Lus Qhia?

Daim ntawv thov piv ntawm glycyrrhizic acid nyob rau hauv ntau yam lag luam yog raws li nram no: 26 feem pua rau cov tshuaj thiab tshuaj pleev ib ce, 70 feem pua rau cov zaub mov, 4 feem pua rau luam yeeb thiab lwm yam.
Hais txog zaub mov:
1. Soy sauce: Ntxiv nrog rau kev txhim kho cov qab ntsev kom txhim kho cov saj ntawm cov kua ntses, glycyrrhizic acid kuj tuaj yeem tshem tawm cov iab saj ntawm saccharin thiab muaj kev sib koom ua ke ntawm cov tshuaj tsw qab.
2. Pickles: Nyob rau hauv txoj kev brine ntawm pickling pickles nrog saccharin, lub iab ntawm saccharin yuav raug tshem tawm. Nyob rau hauv tus txheej txheem ntawm pickling, nws muaj peev xwm kov yeej lub shortcomings ntawm fermentation tsis ua hauj lwm, discoloration thiab hardening tshwm sim los ntawm kev ntxiv tsawg qab zib.
3. Seasoning: Cov khoom no tuaj yeem muab ntxiv nrog cov kua qaub seasoning, seasoning hmoov lossis seasoning ib ntus thaum noj, uas tuaj yeem ua rau kom qab zib thiab txo cov ntxhiab tsw txawv ntawm lwm cov tshuaj seasonings.
4. Taum paste: Pickled herring nrog me me ntses tuaj yeem ua rau kom qab zib thiab ua kom saj txawm.

Glycyrrhizic Acid

Nyob rau hauv cov nqe lus ntawm tshuaj pleev ib ce:
1. Glycyrrhizic acid yog ib tug natural surfactant, thiab nws cov kua aqueous muaj zog foaming khoom.
2. Nws muaj AGTH zoo li kev ua lom lom thiab muaj zog tiv thaiv kab mob thiab tiv thaiv kev ua haujlwm. Nws feem ntau yog siv los kho cov kab mob mucosal, thiab nws tuaj yeem tiv thaiv cov kab mob caries thiab qhov ncauj ulcers thaum siv cov khoom siv tu cev.
3. Nws muaj ntau yam kev sib raug zoo, thiab kev siv hauv cov khoom tu tawv nqaij tuaj yeem txhim kho kev ua tau zoo ntawm lwm yam khoom siv hauv kev tiv thaiv hnub ci, ntxuav hniav dawb, tshuaj tua kab mob, ua kom txias, thiab caws pliav.
4. Composite nrog aescin, aescin, thiab lwm yam, siv los ua cov tshuaj tua kab mob siab.

Glycyrrhizic Acid powder

Cov txheej txheem ntws rau extract glycyrrhizic acid los ntawm licorice
1. Pulverization: Siv cov hauv paus hniav thiab stems ntawm licorice thiab pulverize lawv nyob rau hauv ib tug pulverizer, thiab dhau los ntawm ib tug 20-mesh sieve rau tom qab siv.
2. Extraction: Siv 200kg ntawm cov saum toj no-hais licorice coarse hmoov, muab tso rau hauv 2000L enamel tshuaj tiv thaiv kettle, ntxiv 1200kg dej, maj mam kub mus rau 85-100 degree, do thiab extract rau 2 teev, lim, ntxiv 1000kg dej mus rau lub lim seem, thiab rho tawm ob zaug raws li cov qauv saum toj no, ua ke 3 filtrates.
3. Concentration: Twj cov extract rau hauv enamel evaporator rau concentration, thiab thaum nws yog concentrated mus rau 1/5 ntawm thawj ntim, lim nws thaum nws kub.
4. Kev sib cais: txias cov lim rau hauv chav sov thiab ntxiv 95 feem pua ethanol kom cov ethanol cov ntsiab lus nyob rau hauv cov extract ncav cuag 65 feem pua, cia sawv ntsug rau 24 teev, ces lim kom tshem tawm cov zaub protein thiab polysaccharide.
5. Cov dej nag: Siv cov licorice filtrate, muab tso rau hauv lub tank sedimentation, ntxiv concentrated sulfuric acid los kho cov pH =3, thiab glycyrrhizic acid yuav precipitate, lim, ntxuav ob zaug nrog deionized dej, thiab ces nqus tsev vacuum. .
6. Refining: Ntxiv 3 zaug ntawm acetone rau glycyrrhizinic acid nag lossis daus, cua sov thiab reflux rau extraction rau 3 teev, lim, thiab reflow cov residue rau 2 zaug, muab cov reflux extracts rau 3 zaug, lim, rov qab acetone, thiab tau cov khoom ntub ntawm glycyrrhizic acid.
7. Kev ziab: Muab cov khoom ntub ntawm cov oxalic acid qhuav rau hauv chav ziab kom qhuav, pib tswj qhov kub ntawm 45 degree, qhuav rau 1 teev, maj mam nce qhov kub ntawm 85-95 degree, thiab thaum nws yog hais txog. kom qhuav, nce qhov kub ntawm 100 degrees, thiab thaum kawg ci ntawm 105 degree rau 5 feeb.
8. Pulverization: muab cov glycyrrhizic acid qhuav rau hauv pulverizer kom pulverize, thiab dhau los ntawm 60-80 mesh sieve kom tau glycyrrhizic acid hmoov.

Lub tuam txhab kev taw qhia thiab daim ntawv pov thawj tau txais

Shaanxi Yuantai Biological Technology Co., Ltd (YTBIO) tau tsim nyob rau xyoo 2014, feem ntau muab cov tshuaj ntsuab rho tawm, ua haujlwm kom zoo nkauj raw cov ntaub ntawv, cov khoom organic, thiab lwm yam. Peb muaj peb tus kheej cov chaw tsim khoom, R & D thiab pab pawg soj ntsuam zoo, thiab muaj cov xwm txheej rau kev txhim kho, ntau lawm, thiab kev ruaj ntseg zoo. Tam sim no, peb tau txais ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, organic EU, organic USDA thiab lwm yam ntawv pov thawj. Yog li ntawd, qhov zoo ntawm peb cov khoom yog guaranteed, thiab nws yog peb thawj lub hom phiaj coj cov khoom zoo rau cov neeg muas zaub.

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