Oxmatrine Hmoov

Lub suab endothelial muaj ntau yam kev ua kom tseem ceeb ntawm lub cev, tswj qhov sib cais ntawm cov kev puas tsuaj ntawm tes thiab kev sib cais ntawm cov kauj ruam ntawm lub tsim ntawm atherosclerotic qhov chaw thiab muaj feem cuam tshuam nrog cov kab mob plawv thiab cov myocardial ischemia. Yog li ntawd, tiv thaiv vascular endothelial hlwb yog ib lub tswv yim tseem ceeb kom tiv thaiv thiab kho cov kab mob plawv. Oxmatrine muaj kev tiv thaiv teebmeem. Lub luag haujlwm ntawm ntau vascular endothelial hlwb.
1. Tiv thaiv cov kaus hniav nyeem cov hlwb endothelial
Hauv ib qho kev sim vitro kawm los kawm txog cov qog los tiv thaiv oxiogenesis ntawm oxymatrine, tib neeg umpilical vein endothelial hlwb tau siv los ua kev tswj hwm. Cov txiaj ntsig tau pom tias ib nrab inhibitions conhibitions (IC50) ntawm Oxymatrine nyob rau hauv cov neeg loj hlob ntawm tib neeg umply ntawm tib neeg ump , tuaj yeem ua rau lub xov tooj ntawm tes ua kom huv, feem ntau ntawm cov haujlwm hauv lub xeev apoplicitis, thiab muaj peev xwm ua tau zoo tshaj plaws ntawm kev ua haujlwm ntawm lub cev dej oxidation. Oxmatrine tuaj yeem txhim kho cov kev muaj sia nyob ntawm tus kheej ntawm hypebilical, thiab nce bcl -2 recio thiab down-relfulate caspases. {{6 {}} protein qhia. Lwm txoj kev kawm tau tshaj tawm tias oxymatrine tsis cuam tshuam rau tib neeg umply ntawm tib neeg umbilical yog 1 thiab 3 μmol / l, tab sis 30 μmol / l; 3 μmol / u tuaj yeem tiv thaiv cov kev cuam tshuam ntawm cov piam thaj siab rau tib neeg cov kaus ntxhw txoj hlab ntshav endothelfial. Kev puas tsuaj thiab txo cov kev ua ntawm cov hlwb endothelial; Kev nthuav tawm ntawm A2B receptors thiab ywj pheej chemma cCl5 receptors uas tuaj yeem tiv thaiv cov teeb meem zoo ntawm P38 thiab cov khoom siv ua kom zoo nkauj Opothelial hlwb tshwm sim los ntawm cov hnab looj siab los ntawm kev tswj hwm kev qhia ntawm A2B receptors.
2. Tiv thaiv kev sib deev thiab microovcular endothelial hlwb

Oxmatrine tuaj yeem txhawb nqa cov tshuaj tiv thaiv endothelial ntawm cov kev ua kom muaj kev cuam tshuam rau cov qog ntawm vascular ntawm cov lus qhia txog cov qog ntawm vascular Cov kev tshawb fawb tau tshaj tawm tias kev txhaj tshuaj oxymatrine 120 mg Cov neeg qhia txog cov neeg nyob sab hauv (LT) -1,} -6}, thiab cov qog nqaij daim duab- (tnf-). Lub tshuab hluav taws xob cuam tshuam ntsig txog kev tswj hwm qis-kev qhia ntawm A2B cov receptors, thaiv cov mapk / jnk / jnk / jnk / jnk / jnk / jnk Tsis tas li ntawd, oxymatrine tuaj yeem tiv thaiv endothelial-rau-mesenchmal hloov pauv, thiab inhibit vascular recrotoculating los ntawm downregulating cov kev qhia ntawm hypoxia-inducible factor {16}}.