Txog Cov Lus Qhia ntxaws ntxaws ntawm Nattokinase?

Nattokinase hmoov (NK) (EC 3.4.21.62) yog alkaline serine protease secreted los ntawm Bacillus subtilis (natto). Nws muaj qhov zoo ntawm qhov ntev ib nrab-lub neej, muaj zog tshwj xeeb, cov kev mob tshwm sim me me, thiab tuaj yeem noj ncaj qha ntawm qhov ncauj.
Muab rho tawm los ntawm cov zaub mov natto lossis tsim los ntawm cov kab mob natto, nws yog cov protein uas muaj lub cev hnyav dua li UK, SK, thiab tPA, thiab tuaj yeem nqus tau los ntawm txoj hnyuv. Cov khoom thrombolytic ntawm nattokinase hauv vitro thiab hauv vivo kuj tau txiav txim siab los ntawm kev sim. Nyob rau tib lub sijhawm, nws tau xaus lus tias kev ua haujlwm thrombolytic ntawm nattokinase hauv vivo yog plaub npaug ntawm fibrinolysis. Nws ua sai thiab kav ntev hauv lub cev. Nws tseem tuaj yeem qhib tPA hauv lub cev kom maj mam thiab tsis tu ncua ua rau cov ntshav fibrinolytic ua haujlwm. Cov neeg mob uas muaj kev pheej hmoo ntawm myocardial infarction yuav tsum noj 300, 000 units ntawm urokinase ib zaug, thiab 50 grams natto muaj 800, 000 units ntawm urokinase rau nws cov nyhuv thrombolytic. (Saib daim ntawv qhia los ntawm Matheson thiab lwm tus hais tias txhua gram ntawm qhov hnyav ntawm natto yog kwv yees li 1,600 urokinase units.)
Lub Chaw Tshawb Fawb Kev Kho Mob ntawm St. Mariana Medical University hauv Nyij Pooj thiab Nyij Pooj Lub Tsev Kawm Ntawv ntawm Biological Sciences tsis ntev los no tau tshawb pom tias nattokinase muaj cov nyhuv inhibiting platelet coagulation thiab pab tiv thaiv kev kub siab thiab arteriosclerosis.
Raws li Nikkei Kev Lag Luam Xov Xwm, cov kws tshawb fawb tau nug cov neeg kawm kom haus cov kab lis kev cai ntawm nattokinase thiab tom qab ntawd kuaj lawv cov ntshav. Lawv pom tias 6 teev tom qab noj cov extract, cov coagulation ntawm cov neeg kuaj ntshav platelets tau inhibited. Cov kws tshawb fawb tau xaus lus tias nattokinase muaj kev ua haujlwm ntawm cov ntshav txhaws thiab ua kom cov ntshav ntws zoo.
Yog li ntawd, nattokinase tau dhau los ua ib hom tshuaj tshiab ntawm qhov ncauj thrombolytic tshuaj (thrombolytic tshuaj thib ob), uas ua lub luag haujlwm tseem ceeb hauv kev tiv thaiv thiab kho cov hlab plawv thiab cerebrovascular embolism thiab embolic Alzheimer's disease.

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CAS	133876-92-3
Cov mis mos molecular	C20H23BCl2N2O9
Molecular hnyav	517.12162
EINECS	229-880-6

Lub cev thiab tshuaj muaj zog

1.Stability ntawm Nattokinase
pH stability yog qhov ruaj khov nyob rau hauv lub ntuj pH nqi. Thaum pH tus nqi nce ntawm 7 mus rau 12, nws ruaj khov li ntawm 10 feeb ntawm chav tsev kub. Thaum tus nqi pH qis dua 5, nws tsis ruaj khov thiab poob haujlwm sai. Thaum qhov kub siab tshaj ntawm 60, nws sai sai ua tsis muaj zog vim protein denaturation. Tom qab tsib lub voj voog ntawm kev rov ua kom khov thiab thawing, ntau dua 95% ntawm nws cov haujlwm tseem raug khaws cia, qhia tias khov thiab thawing tsis muaj kev cuam tshuam loj rau kev ua ntawm nattokinase. Thaum nattokinase tov nrog boiled nplej extract, boiled broth, serum albumin thiab gastric mucus protein, lub stability ntawm nattokinase yog ho nce, thiab cov enzyme kev ua si tsis tag txawm nyob rau hauv acidic pH. Thermal stability: Thaum qhov kub qis dua 45 degree, qhov kev ua haujlwm yog qhov ruaj khov. Thaum qhov kub siab tshaj 60 degree, nws yog sai inactivated vim protein denaturation. Kev khov thiab thawing tsis muaj kev cuam tshuam loj rau kev ua haujlwm ntawm nattokinase. Tom qab rov ua kom khov thiab thawing 5 zaug, kev ua haujlwm ntawm nattokinase yog qhov ruaj khov. Cov enzyme tseem tuaj yeem tswj tau ntau dua 95% kev ua haujlwm. Hlau ion stability Cov kev ua ntawm nattokinase kuj cuam tshuam los ntawm qee cov hlau ions. Hg{10}} yuav ua rau nws tsis ua haujlwm. Cu2+, Zn2+, Al3+, Ca2+ thiab lwm yam ions muaj kev cuam tshuam sib txawv ntawm cov enzyme, thaum Mg2+ thiab Co{{16 }} muaj qhov sib txawv inhibitory cuam tshuam rau nws. ua kom cov nyhuv. Kev ruaj ntseg ntawm lwm yam tshuaj, E-ACA thiab EDTA, tsis muaj kev cuam tshuam loj rau kev ua haujlwm ntawm nattokinase, thaum PMSF tuaj yeem cuam tshuam tag nrho nws cov haujlwm. 1 mmol / L DFP thiab neguvon tuaj yeem cuam tshuam tag nrho cov haujlwm ntawm nattokinase.
2.molecular hnyav
Nattokinase yog ib leeg-chain polypeptidase. Vim muaj ntau txoj hauv kev los ntsuas qhov hnyav molecular, ntsuas qhov hnyav molecular kuj tseem txawv. Siv txoj kev SephadexG100 kem gel pom, cov txiaj ntsig tau txais yog 20, 000, thiab cov txiaj ntsig ntsuas los ntawm txoj kev ncig dichroic yog 27,300. Qhov hnyav molecular ntawm lub enzyme raug xam raws li cov amino acid ib ntus yog 27.728.
3.PI tus nqi (isoelectric point)
Siv Svunsson txoj kev kem electrophoresis thiab isoelectric focusing, nattokinase muaj ib tug symmetrical ib plasmin ncov, thiab nws PI tus nqi yog 8.6±0.3. Qhov taw tes isoelectric tuaj yeem muab tau. Thaum cais thiab purifying nattokinase, xav txog kev kho tus nqi pH ze ntawm tus nqi PI, uas muaj txiaj ntsig zoo rau kev ua kom huv ntawm enzyme.
4.Substrate tshwj xeeb ntawm nattokinase
Raws li ib qho serine protease, NK's amidolytic kev ua haujlwm tuaj yeem pom nrog ntau cov khoom siv hluavtaws. Lub substrate rhiab tshaj plaws rau nattokinase yog plasma plasmin substrate, uas yog S2251; Nws muaj qee yam kev ua haujlwm ntawm cov substrates H2DLArgPNA, S2238, S2266 thiab S2302, tab sis pom tseeb tsis muaj zog ntawm S2444 thiab S2484. Nattokinase muaj nws cov amino acid tshwj xeeb ua haujlwm thiab paub qhov chaw rau hydrolyzing proteins.

Lub cev thiab tshuaj muaj zog

A. Nws ceev nrooj denatures thiab ua tsis muaj zog thaum qhov kub siab tshaj 50 degree, tab sis rov ua kom khov thiab thawing tsis tshua muaj txiaj ntsig rau nws.

B. Thaum tus nqi pH nce ntawm 7 mus rau 12, kev ua haujlwm ruaj khov; Thaum tus nqi pH qis dua 5, nws sai sai denatures thiab ua tsis muaj zog. Tus nqi pH hauv ib puag ncig gastric acid tsuas yog nyob nruab nrab ntawm 1.2 thiab 2, yog li nws nyuaj rau nattokinase kom ciaj sia.

C. Nws yog ib qho macromolecular single-chain polypeptidase uas tuaj yeem decomposed rau hauv cov amino acid fragments los yog peptide chains nrog me me molecular hnyav los ntawm plab hnyuv kua txiv (chymotrypsin, trypsin, me me kua txiv, thiab lwm yam).

Cov txiaj ntsig yog dab tsi?

Kev tshawb fawb pom tias nattokinase muaj cov haujlwm fibrinolytic thiab tuaj yeem kho thiab tiv thaiv kab mob thrombotic. Tam sim no, kev tshawb fawb thiab kev siv cov kab mob Natto feem ntau tsom rau lub luag haujlwm ntawm nattokinase. Txawm li cas los xij, ua zaub mov noj qab haus huv, natto kuj muaj ntau yam kev noj qab haus huv, xws li thrombolysis, txo cov ntshav siab, tiv thaiv kab mob, thiab lwm yam. Nws tuaj yeem tiv thaiv kev mob pob txha, txhim kho cov protein digestibility, antioxidant, thiab lwm yam.
1. Thrombolytic nyhuv
Xyoo 1987, Sumi Yoko thiab lwm tus los ntawm Tomisaki Medical University hauv Nyij Pooj tau pom thawj zaug tias cov extracted nattokinase tau siv los kho cov kab mob thrombosis hauv dev thiab ua pov thawj los ua enzyme npaj nrog fibrinolytic kev ua, yog li nws tau hu ua nattokinase.
Kev tshawb fawb ntawm 200 yam khoom nrog qhov ncauj fibrinolytic teebmeem pom tau tias nattokinase yog qhov muaj peev xwm tshaj plaws fibrinolytic protease nrhiav pom tam sim no. Piv nrog urokinase thiab streptokinase, nws muaj ib nrab-lub neej ntev hauv lub cev, tuaj yeem maj mam thiab tsis tu ncua ua rau cov ntshav fibrinolytic ua haujlwm, thiab tsis tshua ua rau los ntshav.
2. Thrombolytic mechanism
① Ua kom lub plasma siab D-dimer zoo, ncaj qha decompose thrombus, thiab ho nce cov ntsiab lus ntawm fibrin degradation khoom FDP;
② Ua kom plasminogen activator, txhawb cov vascular endothelial hlwb los tsim cov ntaub so ntswg plasminogen activator, yaj fibrin, degrade thrombus, thiab qhib urokinase hauv lub cev rau hauv urokinase. Urokinase thiab t-PA ua haujlwm fibrin ua ke. Lysinogen, yaj cov ntshav txhaws. Nws kuj tseem tuaj yeem ua rau cov plasminogen activator blocker PAI-1, ua kom muaj ntau dua urokinase thiab t-PA, thiab txhawb kev tawg ntawm cov ntshav fibrinoprotein. Thiab rhuav tshem cov thrombus;
③ inhibit qhov endogenous thiab exogenous coagulation system kom ua tiav los tiv thaiv thrombolytic thiab thrombolytic. Feem ntau los ntawm kev nce TT, nws txo qis ntshav ELT thiab cuam tshuam rau lub cev coagulation yam tseem ceeb, xws li Fig, thiab ua kom ntev APTT, CT thiab PT;
④ Cov enzyme no yog serine protease uas tuaj yeem ncaj qha hydrolyze cross-linked fibrin, tab sis tsis rhiab rau fibrinogen. Yog li ntawd, thaum lub enzyme exerts nws cov nyhuv fibrinolytic, nws tsis hydrolyze plasma fibrinogen thiab tsis zoo li yuav ua rau los ntshav.
3. Qhov zoo ntawm thrombolysis
Raws li cov tshuaj thrombolytic, nws muaj cov txiaj ntsig zoo hauv qab no: Nattobacterium tau lees paub los ntawm FDA ua cov kab mob zoo hauv kev lag luam khoom noj; Nattokinase muaj qhov hnyav me me thiab yooj yim dua los ntawm tib neeg lub cev; nws tuaj yeem nqus tau los ntawm lub plab zom mov, yog li nws tuaj yeem dhau los ua thawj lub qhov ncauj soluble tshuaj. Thrombus tshuaj; nws tuaj yeem ua ncaj qha rau fibrin thiab ua sai sai; Nws tuaj yeem tsim los ntawm cov kab mob fermentation, yog li nws yog tus nqi qis thiab xav tias yuav tsim los ua tus neeg sawv cev zoo thromboprophylactic.
4. Lwm yam teebmeem tshuaj
Nattokinase muaj angiotensin-hloov enzyme inhibitors uas tuaj yeem kho cov ntshav siab, yog li nws daim ntawv thov hauv kev kho mob ntshav siab tuaj yeem kawm ntxiv. Cov kev tshawb fawb tau pom tias kev tswj hwm qhov ncauj tuaj yeem txo qhov tshwm sim ntawm cov hlab ntsha sib sib zog nqus thrombosis thiab limb edema. Nws kuj tseem ua lub luag haujlwm hauv kev tiv thaiv thiab kho mob pob txha thiab ntshav qab zib.

Anticoagulant nyhuv:Nws muaj cov nyhuv ruaj khov txo platelet aggregation, inhibiting tsim ntawm emboli, thiab txhawb fibrinolysis, yog li tiv thaiv kev tsim thiab tshwm sim ntawm thrombosis. Cov teebmeem no ua rau nattokinase ib qho tshuaj tiv thaiv kab mob.

Ntshav siab txo cov nyhuv:Nws tuaj yeem txo cov ntshav siab los ntawm kev txo cov platelet kev ua haujlwm thiab txhim kho vascular endothelial muaj nuj nqi. Raws li kev tshawb fawb, kev siv ntev ntev ntawm nattokinase tuaj yeem txo cov ntshav siab systolic thiab diastolic hauv cov neeg mob ntshav siab.

Txhim kho lub plawv mob:tuaj yeem tiv thaiv thiab kho kab mob plawv thiab txhim kho cov hlab plawv. Nws txhim kho endothelial cell muaj nuj nqi, txhawb cov ntshav ncig thiab txo cov roj cholesterol, yog li txo qhov kev pheej hmoo ntawm kab mob plawv, mob stroke thiab vascular kab mob.

Anti-inflammatory nyhuv:Nws tuaj yeem cuam tshuam cov lus teb inflammatory thiab txo cov tshuaj insulin. Nws tuaj yeem pab tswj cov kab mob xws li mob caj dab, mob hawb pob thiab mob rheumatism, thiab txo qhov tshwm sim ntawm kev rog, metabolic syndrome thiab lwm yam kab mob.

Ua kom muaj kev ua haujlwm fibrinolytic:Nws ua rau muaj txiaj ntsig tseem ceeb rau kev ua haujlwm fibrinolytic. Nws tuaj yeem txhawb kev tso tawm thiab tsim cov plasmin, nrawm fibrinolysis, pab kho cov ntshav txhaws thiab tiv thaiv cov tsos mob xws li kab mob plawv. Nattokinase kuj tseem tuaj yeem txhim kho lub peev xwm redox ntawm tib neeg cov ntaub so ntswg thiab pab tswj tib neeg kev noj qab haus huv.

Antibacterial nyhuv:Nws tuaj yeem txhim kho tib neeg kev tiv thaiv kab mob thiab muaj cov nyhuv ncaj qha lossis tsis ncaj qha los tiv thaiv kab mob. Nws tuaj yeem txhawb kev loj hlob thiab tso tawm ntawm lymphocytes thiab macrophages, yog li txhim kho tib neeg lub cev tiv thaiv kab mob. Nws tseem tuaj yeem tiv thaiv ntau yam kab mob xws li Staphylococcus aureus thiab Streptococcus pneumoniae.

Antioxidant nyhuv:Nws yog nplua nuj nyob rau hauv flavonoids thiab muaj zog antioxidant nyhuv. Nws scavenges dawb radicals thiab lwm yam teeb meem, txo lub cev raug rau yam xws li ib puag ncig muaj kuab paug thiab kev nyuaj siab txhua hnub.

Dab tsi yog Daim Ntawv Qhia Cov Lus Qhia?

Health Food field:Nattokinase hmoov feem ntau yog siv los ua zaub mov noj thiab khoom noj qab haus huv. Nws tuaj yeem siv los ua khoom noj khoom haus ntxiv uas muab cov khoom noj muaj txiaj ntsig thiab cov enzymes nquag los pab txhim kho lub cev tiv thaiv kab mob, txhawb kev zom zaub mov thiab nqus, thiab txhim kho kev noj qab haus huv tag nrho.

Nattokinase powder

Digestive Health:Nws yog dav siv los txhawb txoj hnyuv. Nws tuaj yeem txhim kho qhov sib npaug ntawm cov hnyuv, txhawb kev zom zaub mov thiab kev nqus ntawm cov zaub mov, thiab txo cov tsos mob ntawm plab hnyuv xws li tsam plab, cem quav, thiab lwm yam.

Ntshav ncig thiab kev kho mob plawv:Nattokinase hmoov muaj anticoagulant thiab fibrinolytic kev ua ub no, uas tuaj yeem txhim kho cov ntshav viscosity, tiv thaiv thrombosis, thiab txhawb cov ntshav ncig. Nws yog dav siv los tiv thaiv cov kab mob plawv thiab cerebrovascular thiab pab txo cov kab mob plawv xws li ntshav siab thiab cov roj cholesterol siab.

Cardiovascular teb:Nattokinase yog dav siv hauv kev tiv thaiv thiab kho cov kab mob plawv thiab cerebrovascular. Nws tuaj yeem txo cov ntshav viscosity, tiv thaiv thrombosis, txhim kho hemodynamics, thiab txo qhov tshwm sim ntawm cov xwm txheej thrombotic. Nattokinase tseem tuaj yeem pab txo cov ntshav siab thiab txhim kho cov hlab plawv.

Anti-thrombotic teb:Nattokinase, raws li lub ntuj anticoagulant, yog dav siv los tiv thaiv kev tsim ntawm thrombosis. Nws tuaj yeem txhawb fibrinolysis, txo platelet aggregation, tiv thaiv qhov tshwm sim thiab nthuav ntxiv ntawm thrombus, yog li txo qhov kev pheej hmoo ntawm cov hlab ntsha sib sib zog nqus, pulmonary embolism thiab lwm yam kab mob ntsig txog thrombosis.

Hauv thaj tsam ntawm kev tiv thaiv kab mob:Nattokinase tuaj yeem txhim kho lub cev tiv thaiv kab mob, txhawb kev ua haujlwm ntawm lymphocytes thiab macrophages, thiab nce cov tshuaj tiv thaiv kab mob. Nws tuaj yeem siv los txhim kho kev tiv thaiv kab mob, tiv thaiv kab mob sib kis, thiab pab kho cov kab mob tiv thaiv kab mob.

Lub tuam txhab kev taw qhia thiab daim ntawv pov thawj tau txais

Shaanxi Yuantai Biological Technology Co., Ltd (YTBIO) tau tsim nyob rau xyoo 2014, feem ntau muab cov tshuaj ntsuab rho tawm, cov khoom siv tshuaj pleev ib ce, cov khoom siv organic, thiab lwm yam. Peb muaj peb tus kheej cov chaw tsim khoom, R & D thiab pab pawg soj ntsuam zoo, thiab muaj cov xwm txheej rau kev txhim kho, ntau lawm, thiab kev ruaj ntseg zoo. Tam sim no, peb tau txais ISO9001, ISO22000, HALAL, KOSHER, HACCP, FDA, organic EU, organic USDA thiab lwm daim ntawv pov thawj. Yog li ntawd, qhov zoo ntawm peb cov khoom yog guaranteed, thiab nws yog peb lub hom phiaj thawj coj cov khoom zoo rau cov neeg muas zaub.

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