Ursodeoxycholic Acid Pwder

Khoom Piav Qhia

Ursodeoxycholic acid yog kev npaj tshuaj lom neeg ntawm ntuj bile acid sib cais los ntawm Xyooj bile. Nws yog cov organic sib tov, tsw ntxhiab thiab iab. Nws yog siv hauv cov tshuaj txhawm rau nce lub zais ntawm cov kua tsib cov kua qaub, hloov kev sib xyaw ntawm cov kua tsib, txo cov roj (cholesterol) thiab cov roj (cholesterol) ester hauv bile, thiab pab cov roj hauv gallstones kom maj mam yaj.

Nws yog epimer ntawm chenodeoxycholic acid. Nws cov pob zeb-ua kom cov nyhuv ua haujlwm zoo ib yam li chenodeoxycholic acid, tab sis chav kho mob yog luv thiab ntau npaum li cas me me. Nws ua ke nrog taurine hauv lub cev thiab tshwm sim hauv cov kua tsib. Nws yog cov kua roj hydrophilic kua qaub thiab lub roj (cholesterol) hauv lub pob zeb roj.

Cov Lus Qhia Txog Cov Khoom

Tus Qauv Txheej Txheeme

Khoom Muaj nuj nqi

1. Ua kom qhov kev tso pa tawm ntawm cov kua tsib acid, ua rau muaj kev hloov pauv ntawm cov kua tsib kua qaub, nce cov ntsiab lus hauv bile, thiab txhawb cov kev cuam tshuam nrog cov kua tsib. Tus nqi nruab nrab ntawm cov kua tsib acid zais cia tau nce los ntawm 1.8mmol ib xuab moos mus rau 2.24mmol tom qab noj nws. Kev siv sijhawm ntev tuaj yeem nce cov ntsiab lus ntawm UDCA hauv bile yam tsis muaj nce hauv cov ntsiab lus ntawm cov kua tsib.

2. Nws tuaj yeem inhibit cov synthesis ntawm cov cholesterol nyob rau hauv lub siab, txo qis cov roj hauv lub plab, cov roj cholesterol ester thiab cov roj saturation index, uas tau txais txiaj ntsig rau maj mam yaj ntawm cov roj hauv cov pob zeb. UDCA tuaj yeem txhawb kev tsim cov kua roj cov kua roj ua kom yooj yim, uas tuaj yeem ua kom nrawm ntxiv ntawm cov roj (cholesterol) los ntawm lub plab mus rau txoj hnyuv.

3. So lub sphincter ntawm Oddi, uas muaj cov nyhuv cholinergic.

4. Txo cov rog rog, nce siab catalase kev ua haujlwm, txhawb cov siab glycogen kom ntau ntxiv, thiab txhim kho daim siab'

5. Nws tuaj yeem txo qhov kev xav ntawm triacylglycerol hauv daim siab thiab ntshav dej.

6. Txwv tsis pub muaj kev zais ntawm digestive enzymes thiab kua txiv.

7. Cov kev tshawb fawb txawv teb chaws tau pom tias ursodeoxycholic acid muaj cov tshuaj tiv thaiv kab mob hauv cov kab mob siab, uas tuaj yeem txo qhov kev qhia ntawm HLAI antigens hauv lub siab ua haujlwm thiab txo qis cov qe ntshav ua haujlwm. Ursodeoxycholic acid zoo dua li chenodeoxycholic acid (CDCA) hauv kev zom cov roj pob zeb hauv lub cev

Daim Ntawv Thov Khoom

Siv ua gallstone dissolving tshuaj. Nws yog tsuas yog siv rau cov roj-cov roj (gallstones) uas tsis tsim nyog rau kev kho mob phais, tshwj xeeb tshaj yog cov uas muaj lub qog ua haujlwm tsis zoo, lub pob zeb uas muaj qhov ntev tsawg dua 15mm, X-ray, tsis-calcified floating roj pob zeb nrog kev kho mob siab. Nws kuj tseem muaj qee qhov kev kho mob rau tus mob siab rau lom, cholecystitis, thawj sclerosing cholangitis, thiab mob cholestatic thawj. Txhim kho qhov ua tau zoo ntawm α-cuam tshuam rau kev kho tus mob muaj kab mob siab ntev.

Tsis tuaj yeem yaj lwm yam kev mob qog. Ursodeoxycholic acid yog qhov tsim nyog rau kev kho mob ntawm lub pob zeb roj, hyperlipidemia, kev puas tsuaj ntawm cov kua tsib lub cev, thawj cov kab mob pob txha, mob siab ntev, mob plab bile tsis zoo, thiab tiv thaiv kev tsis lees thiab kev hloov pauv ntawm daim siab hloov. Lub pob zeb-yaj nyhuv ntawm cov khoom no yog me ntsis tsis muaj zog dua li chenodeoxycholic acid.

Tshuaj sib cuam tshuam

1. Thaum ursodeoxycholic acid sib xyaw ua ke nrog chenodeoxycholic acid, qhov kev txo qis ntawm cov roj cholesterol thiab saturation hauv cov kua tsib yog ntau dua li ob cov tshuaj siv ib leeg, thiab tseem ntau dua cov txiaj ntsig ntxiv ntawm ob cov tshuaj. Qhov no tej zaum yuav cuam tshuam nrog cov kev sib txawv ntawm kev txiav txim ntawm ob lub tshuaj rau ntawm cov hluavtaws, kev zom khoom noj thiab tua kinetics ntawm cov cholesterol.

2. Tshuaj tiv thaiv qhov ncauj tuaj yeem nce bile saturation thiab cuam tshuam rau kev ua tau zoo. Lwm txoj kev tswj tsis pub lwm tus yuav tsum tau ua thaum kho.

3. Cov nplaim hluav taws xob muaj peev xwm khi cov kua tsib kua qaub hauv kev kuaj hauv vitro, thiab thaum sib koom ua ke, nws yuav cuam tshuam rau kev nqus ntawm cov tom kawg.

4. Aluminium-antacids tuaj yeem nqus cov kua tsib cov kua qaub hauv kev kuaj hauv vitro, thiab tuaj yeem txo qhov nqus ntawm ursodeoxycholic acid thaum siv los ua ke.

5. Vim tias cholestyramine thiab colestipol tuaj yeem khi cov kua tsib kua qaub hauv kev kuaj hauv vitro, lawv tuaj yeem cuam tshuam nrog kev nqus ntawm cov tom qab thaum siv los ua ke.

Cim npe nrov: ursodeoxycholic kua qaub