Yuav ua li cas liquiritin siv zog antioxidant thiab anti {{{in inflammatory teebmeem?

Dej cawv, ib qho flavonoid compound muaj nyob rau hauv Licorice cag, tau mus rau lub hauv paus tseem ceeb nyob rau xyoo tsis ntev los no vim nws cov antioxidant thiab anti {{pob khoom. Qhov sib txawv no tau qhia txog cov lus cog tseg hauv ntau qhov kev thov, ua rau muaj kev ntsuas kev pom zoo tshaj plaws. Hauv cov ntawv sau thoob plaws, peb yuav tshem tawm cov txheej txheem sib xws hauv qab cov khoom muaj txiaj ntsig, tshuaj xyuas nws cov qauv molecular, txoj kev cellular, thiab sib piv potencing.

Lub cim cov qauv molecular ntawm cov dej cawv ua si ib lub luag haujlwm tseem ceeb hauv nws cov antioxidant thiab anti {{pob muaj peev xwm. To taub tus qauv no muaj kev pom pom rau hauv cov khoom sib cuam tshuam nrog cov khoom ntawm cov cell los ua kom muaj txiaj ntsig zoo.

Tshuaj lom neeg tshuaj lom neeg thiab cov pab pawg ua haujlwm

Dej cawvbelongs rau tsev neeg flavonoid, tshwj xeeb tau cais raws li Flavanone glycoside. Nws cov mis mis yog c21h2O9, muaj ntawm flavanone core sib txuas nrog cov piam thaj ua ke. Lub xub ntiag ntawm ntau cov pab pawg hydroxyl hauv nws cov qauv ua rau nws cov khoom tiv thaiv kab mob antioxidant tseem ceeb.

Lub hauv paus flavanone ntawm cov khoom muaj 2-phenylchroman-4-ib tus qauv, uas yog lub luag haujlwm rau ntau cov kev ua ub no roj ntsha. Cov piam thaj moiety txuas rau cov tub ntxhais no ua tiav rau cov solubility thiab bioavailability, tso cai rau nws yooj yim nqus thiab faib thoob plaws lub cev.

Qauv -} kev ua ub no

Cov txheej txheem ntawm atoms thiab cov pab pawg ua haujlwm hauv cov qauv kev txiav txim siab nrog kev sib txuam nrog cov khoom siv cellular thiab nws muaj peev xwm neutralize dawb radicals. Cov pab pawg hydroxyl ua raws li cov neeg pab nyiaj txiag hydogen, zoo rau cov roj oxygen reactive uas tuaj yeem ua rau oxidative kev ntxhov siab thiab oxidation.

Ntxiv mus, txoj kev teeb tsa ntawm Flavonoid Core tso cai rau cov khoom lag luam ntawm DNA kev tiv thaiv DNA kev puas tsuaj los ntawm oxidative kev ntxhov siab. Cov qauv qauv no kuj tseem ua rau cov kua roj ua ke nrog ntau cov enzymes thiab recibutors koom nrog rau nws cov anti- Inflammatory teebmeem.

Dej cawv lub antioxidant thiab anti {- pa taws kub yog kho kom haum los ntawm ntau txoj kev celliv. Los ntawm kev cuam tshuam cov kab ke no, qaug cawv tuaj yeem hloov kho lub cev teb rau oxidative kev ntxhov siab thiab mob tag nrho kev noj qab haus huv thiab zoo- ua.

Antioxidant Kws Muaj Txuj Ci

Dej cawvUa kom muaj ntau lub tshuab tiv thaiv kab mob antioxidant nyob rau hauv cells:

• NRF2 txoj kev ua kom muaj zog: cov khoom tau pom tias ua kom lub Nuclear Perforor Erythroid 2 (NRF2) Txoj kev, ib cov lus teb ntawm cov lus teb cellular. Qhov kev ua kom muaj zog no ua rau muaj kev nthuav dav ntau cov enzymes xws li superoxide dismutase (sod), catalase, thiab glutathione peroxidase.
• Ncaj Nraim Ros scavening: Raws li tau hais ua ntej, cov khoom tuaj yeem tawm ncaj qha ros los ntawm nws pab pawg hydroxyl, tiv thaiv oxidative kev puas tsuaj rau cov khoom siv cellular.
• Cov tshuaj chelation: Cov khoom tau pom tias muaj peev xwm ua kom muaj peev xwm chelate hlau ions, uas tuaj yeem ua tau cat tsim ntawm Ros. Los ntawm khi rau cov ions, cov khoom txo lawv lub peev xwm los tsim cov teeb meem dawb radicals.

Anti -} ua pob tw me me

Lub anti -} mob kub ntawm cov dej cawv yog kho tau los ntawm ntau cov phiajcim txoj hauv kev:

• Nf {{{{{}} κ Cov khoom lag luam inhibition: cov khoom tau raug pom los ntawm kev ua kom zoo ntawm Nuclear Factor Kappa B (N} κ} κ κ Qhov kev txwv Inhibition no hauv kev txo ntau ntau lawm ntawm pro {{3} pa cytokines thiab enzymes.
• Mapk Cov Kev Ua Si: Cov khoom tuaj yeem hloov cov mitogen - ™ activ່ວນ ™ activ່ວນ ™ activ່ວນ activ activase (Mapk) txoj kev nyob rau hauv cov lus teb tseem ceeb hauv cov lus teb cellular Los ntawm kev cuam tshuam txoj kev no, cov khoom tuaj yeem pab tswj cov khoom siv ntau yam khoom.
• Cox-2 thiab INSOS SORCERY: kev tshawb fawb tau pom tias cov khoom lag luam tuaj yeem cuam tshuam cov cyclooxyenase-2 (inos), ob qho enzymes uas pab txhawb rau qhov mob.

Kom txaus siab rau antioxidant thiab anti {{{{{ Qhov kev sib piv no muab cov kev pom zoo rau hauv cov kua dej hauv cov kua zaub thiab cov ntawv thov muaj peev xwm.

Dej cawv vs. cov antioxidants

Thaum piv rau cov antioxidants xws li vitamin C, Vitamin E, thiab Beta- Carotene,Dej cawvtau qhia kev cog lus tias:

• Dawb radical scavenging muaj peev xwm: hauv venro kev tshawb fawb tau pom tias cov khoom lag luam nthuav tawm muaj peev xwm tshaj plaws rau cov vitamin C thiab Vitamin E hauv qhov kev ua haujlwm zoo. Qhov no qhia tau tias cov khoom yuav ua tau zoo dua hauv kev cuam tshuam dawb radicals.
• Lipid Peroxidation Inhibition: Cov khoom tau muaj lub peev xwm zoo tshaj plaws rau kev tso cai lipid peroxidation piv rau qee cov tshuaj tua kab mob antioxidants. Cov cuab yeej no yog qhov tshwj xeeb tshaj yog nyob rau hauv kev tiv thaiv cellular ntawm cov mis nyuj los ntawm oxidative kev puas tsuaj.
• Synergistic cuam tshuam: nthuav tawm, cov khoom tau pom tias ua haujlwm synergistically nrog rau lwm cov tshuaj antioxidants, txhim kho lawv qhov ua tau zoo tag nrho. Qhov no qhia tau tias cov khoom yuav yog qhov tseem ceeb ntxiv rau cov qauv tshuaj tiv thaiv kab mob antioxidant.

Dej cawv vs. lwm yam flavonoids

Muab piv rau cov dej cawv rau lwm tus flavonoids muab cov kev pom ntxiv mus rau hauv nws cov khoom ntiag tug:

• Anti {-} Kev tshawb xyuas tau pom tseeb tias cov khoom lag luam uas pom tau yooj yim lossis cov tshuaj lom neeg zoo li cov qauv ntawm cov qauv.
• Bioavailability: glycoside qauv ntawm cov khoom yuav confer adjessed bioavailability piv rau qee lwm qhov ua rau nws cov txiaj ntsig hauv Vivo.
• Cov hom phiaj cellular: thaum ntau ntau flavonoids sib qhia cov khoom siv tshuaj tiv thaiv kab mob ib yam, xws li cov kev cuam tshuam ntawm tes, teeb tsa nws sib nrug los ntawm lwm cov chaw nyob hauv nws cov chav kawm.

Hauv kev xaus,Dej cawvSawv tawm los ntawm cov tshuaj tiv thaiv muaj zog thiab anti {{- pa taws qauv uas ua rau nws cuam tshuam nrog ntau txoj kev cell. Nws lub peev xwm los qhib kev tiv thaiv kab mob antioxidant, ntsuas kev cuam tshuam rau cov kab mob antioxidant ua rau muaj kev sib tw noj qab haus huv ntxiv rau ntau qhov kev thov kev noj qab haus huv.

Raws li kev tshawb fawb txuas ntxiv mus unravel tag nrho cov peev xwm ntawm cov dej cawv, nws yog qhov tseeb hais tias qhov no antioxidants thiab anti {{ode infl { Rau cov lag luam hauv cov khoom noj kev noj qab haus huv, nutraceutical, thiab cov khoom siv rau cov khoom siv rau kev sib tw hauv kev sib tw xav tau, kev daws teeb meem ntuj.

Puas yog koj yog cov chaw tsim khoom lossis hom saib cov hlua khi cov hwj chim ntawm cov dej cawv hauv koj cov khoom? Shaanxi Yuantai Biological Technology Co., Ltd (YTBIO) yog cov khoom lag luam uas tau ua haujlwm siab thiab lwm yam khoom xyaw. Nrog peb lub xeev - ntawm {4 4} {{{5, {{5000} {5, Txawm hais tias koj tab tom tsim cov khoom noj vegan zaub mov, pab kev ncaws pob, lossis pab pawg ua haujlwm, peb pab neeg ua haujlwm, kev noj qab haus huv- kev txhawb nqa cov khoom lag luam. Tiv tauj peb rau hnub nosales@sxytbio.comYog xav paub ntau ntxiv txog cov cawv npaum li cas tuaj yeem txhim kho koj cov khoom kab thiab tsav koj lub lag luam tom ntej.

Ntawv Sawv cev

1. Zhang, L., li al. (2019). "Dej hiav txwv Antioxidant thiab anti - inflammatory cuam tshuam los ntawm kev ua haujlwm ntawm tus nrf2 txoj kev." Phau ntawv Journal ntawm cov tshuaj molecular, 97 (8), 1143-1153.

2. Wang, Y., li al. (2020). "Kev sib piv ntawm antioxidant thiab anti - kev ua si ntawm cov dej cawv thiab lwm yam flavonoids." PhyTomedicine, 78, 153316.

3. Chen, X., li al. (2018). "Molecular txheej txheem ntawm cov dej cawv hauv modulating cov lus teb mob thiab kev ntxhov siab oxidative." Kev tshawb nrhiav chaw muag tshuaj, 131, 191-202.

4. Liu, H., li al. (2021). "Dej cawv: Ib qho kev tshuaj xyuas txhua tus ntawm nws cov kev ua si ntawm cov tshuaj thiab cov molecular." Biomedicine & Kws muag muag tshuaj, 141, 111880.

5. Kim, J., li al. (2017). "Aantioxidant thiab anti {- incammatory cuam tshuam ntawm cov cawv hauv cov qauv ntawm tes thiab tsiaj." Phau ntawv sau txog kev ua liaj ua teb thiab 65 (16), 3406-3416.

6. Zhao, z., li al. (2022). "Cov neeg sawv cev ua kom muaj peev xwm kho tus neeg sawv cev: Cov xwm txheej tam sim no thiab kev pom yav tom ntej." Frontiers hauv Pharmacology, 13, 841589.