Nicotinamide Riboside Chloride txawv ntawm NMN li cas?

Nicotinamide riboside chloride hmoov(NRC) thiab nicotinamide mononucleotide (NMN) yog ob lub tebchaw uas tau txais kev saib xyuas ntau rau lawv cov teebmeem ntawm cell noj qab haus huv thiab lub neej. Ob leeg ntawm cov molecules no tuaj ua ntej NAD +, uas yog ib qho tseem ceeb molecule rau kev ua lub zog hauv hlwb thiab kho DNA. Tab sis cov tshuaj no txawv ntawm txoj hauv kev uas ua rau lawv sawv. Cov khoom no mus rau hauv kev nthuav dav txog yuav ua li cas nicotinamide riboside chloride thiab NMN sib txawv los ntawm kev saib lawv cov qauv, cuam tshuam rau cov metabolism, thiab qhov chaw hauv khw.

Molecular Structure thiab Composition

Ib qho tseem ceeb tshaj qhov sib txawv ntawm NMN thiabnicotinamide riboside chlorideyog tus qauv molecular ntawm txhua yam ntawm cov tebchaw no. Nicotinamide riboside (NRC) yog ib daim ntawv ntsev ntawm nicotinamide riboside. Nws yog tsim los ntawm ib tug molecule ntawm nicotinamide uas yog bonded rau ib tug ribose qab zib uas muaj ib tug chloride ion. Lub nucleotide hu ua NMN, ntawm qhov tod tes, yog tsim los ntawm ribose, nicotinamide, thiab phosphate pawg.

Loj thiab Cellular Uptake

Lub cellular absorption mechanisms ntawm NRC thiab NMN raug cuam tshuam los ntawm cov qauv kev hloov pauv ntawm ob, feem. Vim hais tias nws yog ib tug me me molecule, nicotinamide riboside chloride hmoov muaj peev xwm los pab txhawb passive diffusion hla cell membranes yooj yim dua. Vim tias NMN loj dua lwm cov molecules vim nws cov phosphate pawg, nws yuav xav tau cov thauj tshwj xeeb txhawm rau nkag mus rau cov hlwb.

Převod NAD na TXK

Muaj qhov sib txawv me me ntawm txoj kev metabolic ntawm NRC thiab NMN, txawm hais tias ob qho tib si ua haujlwm ua ntej rau NAD+. Hauv lub cell,nicotinamide riboside chloridenkag mus rau qhov kev hloov pauv uas hloov pauv mus rau NMN ua ntej nws hloov mus rau NAD+. Tus lej hloov pauv cov kauj ruam uas yuav tsum tau muaj rau NMN raug txo vim nws twb yog ib kauj ruam ze dua rau NAD+.

Bioavailability thiab Absorption

Ib lub ntsiab lus ntawm kev tshawb fawb uas tam sim no tab tom ua yog bioavailability ntawm cov tshuaj no. Txij li thaum NRC yog qhov me me thiab muaj peev xwm raug coj mus ncaj qha los ntawm cov hlwb, muaj qee qhov kev tshawb fawb qhia tias nws yuav muaj bioavailability ntau dua li lwm cov tshuaj. Cov kev tshawb fawb tsis ntev los no, ntawm qhov tod tes, tau nthuav tawm qee cov NMN thauj khoom hauv qee cov ntaub so ntswg, uas hu rau cov lus nug txog cov kev xav uas tau ua yav dhau los hais txog nws cov kev txwv kev nqus.

Cov ntaub so ntswg-Cov teebmeem tshwj xeeb

Nws muaj peev xwm hais tias qee lub cev thiab cov ntaub so ntswg yuav siv ib qho precursor ntau dua li lwm tus thaum lub sijhawm ua haujlwm. Raws li ib qho piv txwv, ib tug xov tooj ntawm cov kev tshawb fawb qhia tias lub siab yuav tau txais ntau dua rau kev siv NRC, thaum lub sij hawm ib co cheeb tsam ntawm lub paj hlwb tej zaum yuav ntau inclined mus txais NMN. Tag nrho cov txiaj ntsig ntawm ib qho molecule hauv ntau yam txheej txheem physiological tej zaum yuav cuam tshuam los ntawm kev nyiam ntawm cov ntaub so ntswg sib txawv.

Kev Ua Lag Luam Kev Ua Lag Luam thiab Kev Paub Txog Cov Neeg Siv Khoom

Nicotinamide riboside chloride hmoovthiab NMN muaj ob qho tib si tsim muaj qhov loj hauv kev lag luam ib puag ncig los ntawm lawv cov khoom lag luam. Ib qho tseem ceeb ntawm kev tshawb fawb thiab kev lag luam kev ua ub no tau ua rau muaj kev muaj koob meej ntawm NRC, uas nquag muaj nyob rau hauv cov ntawv patented. Txawm hais tias nws yog ib yam khoom tshiab ntawm kev ua lag luam, NMN tau txais kev nyiam sai sai, tshwj xeeb hauv kev lag luam los tiv thaiv - kev laus thiab kev ua neej ntev.

Kev tshawb fawb thiab kev tshawb fawb soj ntsuam

Lub cev ntawm kev tshawb fawb nyob ib puag ncig cov tebchaw no txuas ntxiv mus. NRC tau dhau los ntawm ntau qhov kev sim tshuaj tib neeg, tshuaj xyuas nws cov teebmeem ntawm ntau yam kev noj qab haus huv thiab kev laus. NMN, thaum muaj lub hauv paus kev tshawb fawb preclinical zoo, tam sim no pom kev nce hauv tib neeg kev tshawb fawb. Qhov kev tshawb fawb tsis tu ncua no ua rau muaj kev nkag siab hloov zuj zus ntawm txhua qhov sib xyaw ua ke cov txiaj ntsig zoo thiab kev siv.

Cov khoom tsim thiab kev siv

Ntau qhov sib txawv ntawm nicotinamide riboside chloride hmoov yog muaj rau kev yuav khoom. Cov formulations muaj xws li tshuaj ntsiav, tshuaj, thiab hmoov. Nws yog haum rau ntau yam khoom siv vim nws ruaj khov thiab nws muaj peev xwm yaj. Hauv cov hlab ntsha zoo sib xws, NMN muaj ntau yam, tab sis, vim qhov sib txawv ntawm nws cov qauv molecular, nws cov qauv yuav hu rau ntau yam kev xav.

Thaum ob qho tib si nicotinamide riboside chloride thiab NMN qhia cov lus cog tseg hauv kev txhawb nqa cellular noj qab haus huv thiab muaj feem cuam tshuam txog hnub nyoog - cuam tshuam txog kev poob qis, lawv tsis yog cov sib xyaw ua ke. Lawv qhov sib txawv ntawm cov qauv ua rau muaj kev hloov pauv hauv cellular uptake, metabolism, thiab tej zaum cov ntaub so ntswg - cov teebmeem tshwj xeeb. Kev xaiv ntawm NRC thiab NMN tuaj yeem nyob ntawm cov hom phiaj kev noj qab haus huv tshwj xeeb, tus kheej lub cev, thiab cov txiaj ntsig kev tshawb fawb tsis tu ncua.

Raws li thaj tsam ntawm NAD + cov thawj coj tseem tab tom nce mus ntxiv, nws zoo li tias peb txoj kev nkag siab ntawm cov tebchaw no yuav ua kom zoo dua qub, uas ua rau muaj kev xav tau ntau dua thiab cov qauv tsim. Txog tam sim no, ob qho tib si NRC thiab NMN tseem yog cov cuab yeej tseem ceeb hauv kev nrhiav kev ua haujlwm zoo ntawm tes thiab kev laus noj qab haus huv.

Koj puas xav ntxiv - zoo nicotinamide riboside chloride rau koj cov khoom lag luam? Nicotinamide riboside chloride chaw tsim tshuaj paus Shaanxi Yuantai Biological Technology Co., Ltd (YTBIO) yog tib lub tuam txhab koj xav pom. Pebnicotinamide riboside chloride hmoovyog qhov zoo tshaj plaws hauv kev lag luam vim tias peb ua cov khoom noj khoom haus noj qab haus huv thiab cov khoom xyaw ua kom zoo nkauj uas ua tau raws li cov qauv saum toj kawg nkaus hauv kev lag luam.

Ntau daim ntawv pov thawj, xws li HACCP, ISO9001, ISO22000, HALAL, KOSHER, FDA, thiab EU & NOP Organic, qhia tias peb mob siab rau qhov zoo. Peb paub tseeb tias txhua pawg ntawm peb cov nicotinamide riboside chloride ua tau raws li cov qauv siab ntawm cov tuam txhab ntxiv thiab cov vitamin, cov khoom noj khoom haus kis las, thiab cov chaw tsim khoom noj qab haus huv nrog peb cov kev txiav - cov chaw ntug thiab kev tswj xyuas nruj.

Txij li thaum YTBIO muaj chaw ua haujlwm hauv Tebchaws Europe thiab Tebchaws Meskas, peb tuaj yeem xa khoom sai sai rau cov neeg siv khoom thoob plaws ntiaj teb. Peb pab neeg muag khoom txawj pab cov neeg siv khoom hauv ntau tshaj 100 lub teb chaws thiab 500 kev lag luam, thiab peb muab cov kev pabcuam zoo tshaj plaws thiab kev txhawb nqa tom qab muag.

YTBIO muaj cov txuj ci thiab cov cuab yeej los pab koj nrog koj cov haujlwm, txawm tias koj tab tom ua cov tshuaj vegan, cog-cov zaub mov, lossis cov khoom noj tshiab. Peb cov kev daws teeb meem ntuj thiab cov organic tuaj yeem pab koj ua kom koj cov khoom lag luam sawv tawm ntawm tus so thiab muab koj ib qho ntug hauv khw.

Tsis txhob plam lub sijhawm los koom tes nrog tus thawj coj hauv cheeb tsam. Hu rau YTBIO hnub no ntawmsales@sxytbio.comkom paub ntau ntxiv txog peb cov khoom siv nicotinamide riboside chloride thiab peb tuaj yeem pab txhawb koj txoj kev lag luam loj hlob li cas. Cia peb ua haujlwm ua ke coj kev noj qab haus huv thiab kev zoo nkauj rau txhua tsev neeg.

Cov ntaub ntawv

1. Trammell, SA, et al. (2016). Nicotinamide Riboside yog qhov tshwj xeeb thiab qhov ncauj Bioavailable hauv nas thiab tib neeg. Nature Communications, 7, 12948.

2. Ratajczak, J., et al. (2016). NRK1 tswj cov nicotinamide mononucleotide thiab nicotinamide riboside metabolism hauv cov tsiaj txhu. Nature Communications, 7, 13103.

3. Yoshino, J., et al. (2018). Nicotinamide mononucleotide, ib qho tseem ceeb NAD + nruab nrab, kho cov kab mob pathophysiology ntawm kev noj haus- thiab hnub nyoog-induced ntshav qab zib hauv nas. Cell Metabolism, 14(4), 528-536.

4. Martens, CR, et al. (2018). Kev noj qab haus huv nicotinamide riboside ntev yog qhov zoo- zam thiab txhawb nqa NAD+ hauv nruab nrab noj qab haus huv - cov neeg laus thiab cov laus. Nature Communications, 9(1), 1286.

5. Airhart, SE, et al. (2017). Ib qho qhib -label, tsis yog-randomized txoj kev tshawb fawb ntawm pharmacokinetics ntawm cov khoom noj khoom haus ntxiv nicotinamide riboside (NR) thiab nws cov teebmeem ntawm cov ntshav NAD+ qib hauv cov neeg ua haujlwm noj qab haus huv. PLoS Ib, 12(12), e0186459.

6. Grozio, A., et al. (2019). Slc12a8 yog nicotinamide mononucleotide transporter. Xwm Txheej Metabolism, 1(1), 47–57.