CAS nr: 35354-74-6
Cov mis mos molecular: C18H18O2
Molecular Luj: 266.33
EINECS tus lej: 609-119-8
Botanical qhov chaw: Houpoea officinalis (Rehder & EH Wilson)
Cog lus qhia:
Houpoea officinalis (Rehder & EH Wilson) NH Xia & CY Wu), tsob ntoo deciduous ntawm genus Magnolia ntawm tsev neeg Magnoliaceae. Cov tawv nqaij yog tuab, xim av, tsis tawg, oily thiab ntsim; nplooj yog loj, concentrated nyob rau sab saum toj ntawm ceg, oblong-ovate, nrog grey pubescence thiab dawb hmoov hauv qab no; paj yog dawb thiab tsw; cov txiv hmab txiv ntoo feem ntau yog oblong thiab oval; Cov noob yog daim duab peb sab thiab obovate; Lub sij hawm flowering yog los ntawm lub Tsib Hlis mus rau Lub rau hli ntuj, thiab fruiting lub sij hawm yog los ntawm Lub yim hli ntuj mus rau Lub kaum hli ntuj. Magnolia officinalis yog cov nroj tsuag ntawm genus Magnoliaceae, faib hauv Shaanxi, Gansu, Anhui, Zhejiang thiab lwm thaj chaw. Muaj txog 30 hom tsiaj hauv kuv lub tebchaws, ntawm 20 hom tsiaj muaj nqi tshuaj. Magnolia officinalis loj hlob ntawm tshav ntuj slopes thiab hav zoov ntug nrog fertile thiab tob av ntawm qhov siab ntawm 300-1700m. Magnolia officinalis yog tsob ntoo mesophytic uas nyiam lub teeb thiab xav tau ntxoov ntxoo hauv nws cov tub ntxhais hluas theem; nws nyiam qhov txias, ntub, huab cua thiab kub kub. Nws loj hlob zoo tshaj plaws ntawm me ntsis acidic los yog nruab nrab av nrog tob, fertile, xoob, humus-nplua nuj, thiab zoo-drained av. Feem ntau loj hlob nyob rau hauv sib xyaw deciduous broad-leaved forests, los yog nyob rau hauv evergreen broad-leaved forests. Txoj kev propagation ntawm Magnolia officinalis yog noob propagation.
Kev sau thiab khaws cia cov ntaub ntawv raw:
Cov ntoo tuaj yeem txiav thiab tev tawm tom qab ntau tshaj 20 xyoo ntawm kev cog qoob loo. Nws yuav tsum tau ua thaum lub sij hawm nce siab tshaj plaws txij lub Plaub Hlis mus txog Lub Yim Hli. Lub hauv paus bark thiab ceg tawv yog qhuav ncaj qha rau hauv qhov ntxoov ntxoo los yog dov thiab qhuav, thiab hu ua cag bark thiab ceg tawv; Tom qab cov tawv ntoo tuaj yeem girded los yog stripped, yob yog scalded nyob rau hauv boiling dej kom txog thaum muag muag, thiab ces muab faus rau hauv qhov chaw ntub dej kom tawm hws. Thaum sab hauv los yog hla ntawm cov tawv ntoo hloov xim liab-xim av los yog xim av, thiab ua oily los yog ci, dov txhua ntu ntawm cov tawv ntoo rau hauv ob lub raj, khi nws nruj nreem nrog xyoob tua, txiav ob qho kawg, thiab ua kom qhuav.
Honokiol yog ib qho pleiotropic compound muab rho tawm los ntawm cov tawv ntoo lossis cov cag ntoo ntawm cov nroj tsuag magnolia xws li Magnolia grandiflorum thiab Magnolia alba. Honokiol yog ib qho isomer ntawm magnolol. Nws yog tan rau dawb hmoov zoo. Nws yog ib qho dimer tsim los ntawm polymerizing sab saw ntawm ib phenylpropanoid thiab benzene core ntawm lwm phenylpropanoid. Nws yog hu ua Lignans tshiab, pom feem ntau hauv cov nroj tsuag Lauraceae, yog cov tshuaj tua kab mob thiab tiv thaiv kab mob ntawm cov tshuaj suav tshuaj Magnolia officinalis. Honokiol thiab honokiol yog cov xim tsis muaj koob zoo li cov muaju, yooj yim soluble hauv benzene, ether, chloroform, ethanol, thiab lwm yam, tab sis nyuaj rau yaj hauv dej. Nws reacts nrog ferric chloride methanol tov los tsim xiav-dub xim, reacts nrog Millon's reagent los ua xim av precipitate, thiab reacts nrog phloroglucinol hydrochloric acid tov los tsim liab precipitate.
Honokiol muaj qhov pom tseeb thiab ntev ntev hauv nruab nrab cov leeg so, hauv nruab nrab paj hlwb inhibitory teebmeem, tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, tiv thaiv kab mob, antioxidant, tiv thaiv kev laus, tiv thaiv qog, txo cov roj cholesterol thiab lwm yam tshuaj. Nws yog siv rau kho mob enteritis, kab mob los yog amoebic dysentery, mob gastritis, thiab lwm yam. Ntawm lawv, nyob rau hauv cov nqe lus ntawm antibacterial nyhuv, honokiol muaj ib tug tseem ceeb antibacterial kev ua si tawm tsam Gram-positive kab mob, acid-resistant kab mob, thiab filamentous fungi, muaj ib tug ntau. Cov tshuaj tua kab mob tseem ceeb tiv thaiv Streptococcus mutans, thiab muaj zog tiv thaiv kev tiv thaiv Staphylococcus aureus. Clinically, nws yog tsuas yog siv los ua tshuaj kom tshem tawm lub hauv siab thiab plab plab, ua rau lub hauv paus paj hlwb, so cov leeg hauv cov neeg ncaws pob, thiab yog cov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob. Tsis tas li ntawd, kev siv tshiab ntawm honokiol tuaj yeem txuas mus rau cov kab mob puas hlwb.
Txoj kev Extraction
1. Cov txheej txheem ntau lawm ntawm Magnolia officinalis extract (kua extract): Sib tsoo Magnolia officinalis thiab tsau nws nrog ethanol rau 12 teev. Muab tso rau hauv lub tog raj kheej percolation thiab percolate nrog li 12 npaug ntawm ethanol. Sau cov kua percolation thiab rov qab cov ethanol nyob rau hauv lub siab txo kom txog thaum nws tag. , tau cov kua extract. Cov txiaj ntsig yog li 9%, cov ntsiab lus khoom yog 85.0%, nws muaj ntau dua 11.0% magnolol thiab ntau dua 5.0% honokiol.
2. Extraction thiab sib cais ntawm magnolol thiab honokiol. Siv cov hmoov coarse ntawm magnolia bark qhuav tawv, ntxiv 1/5 tus nqi (W / W) ntawm cov hmoov nplej sai, sib tov zoo, thiab infiltrate nrog 15-20 zaug ntawm cov dej distilled. Ntxiv hydrochloric acid rau percolate Chemicalbook los kho cov pH rau 2 txog 3 thiab cia nws sawv. Sau cov precipitated precipitate, ntxuav nws nrog distilled dej kom txog thaum pH tus nqi ntawm precipitate yog 6 mus rau 7, qhuav nws, ntxiv alumina (1:10), sib tov sib npaug, muab tso rau hauv ib tug extractor, thiab extract nrog cyclohexane. Tsom ntsoov rau cyclohexane extract thiab cia nws txias, dawb crystals yuav precipitate, thiab muaju thiab niam cawv yuav tau los ntawm kev pom. Crystallization yog recrystallized nrog cyclohexane, uas yog honokiol. Tom qab niam cawv yog concentrated, crystals precipitate, thiab cyclohexane yog recrystallized kom tau cov xim tsis muaj xim tsis muaj kob, uas yog magnolol crystals. Cov txiaj ntsig ntawm magnolol yog 85%, thiab cov txiaj ntsig ntawm honokiol yog 74%.
Daim ntawv thov teb: zaub mov, khoom noj khoom haus, tshuaj
Daim ntawv thov:suppositories, lotions, ntsiav tshuaj, capsules, thiab lwm yam.
Khaws hauv qhov txias:qhuav qhov chaw deb ntawm lub teeb thiab kub. Cia kub: 2-8 degree .
Yog koj xav paub ntxiv, thov hu rausales@sxytbio.com,Nyem qhov no los tiv tauj peb hauv online
