Thaum peb laus lawm, peb lub cev mus dhau ntau qhov kev hloov pauv uas tuaj yeem cuam tshuam rau peb txoj kev noj qab haus huv thiab lub zog tag nrho. Kev tsim khoom thiab kev saib xyuas lub zog hauv peb lub hlwb yog ib feem tseem ceeb ntawm kev noj qab haus huv lom neeg.Nicotinamide riboside chloride hmoov(NR chloride) yog ib qho chaw uas tau pom ntau cov lus cog tseg hauv kev tshawb fawb txog kev tiv thaiv - kev laus thiab lub zog ntawm tes. Cov khoom no yuav tham txog yuav ua li cas NR chloride pab cov hlwb ua lub zog thiab yuav siv li cas hauv cov khoom siv los tiv thaiv -.
NR Chloride lub luag haujlwm hauv cellular zog tsim
NR chloride, tseem hu uanicotinamide riboside chloride, yog ib qho tseem ceeb hauv kev tsim lub zog ntawm tes vim tias nws ua haujlwm ua ntej rau nicotinamide adenine dinucleotide (NAD +), coenzyme uas tsim nyog rau ntau yam txheej txheem metabolic vim nws muaj ntau txoj haujlwm. Muaj ntau txoj haujlwm ntawm tes uas NAD + tau koom nrog, suav nrog cov hauv qab no:
Mitochondrial muaj nuj nqi
Mitochondria feem ntau hu ua lub zog ntawm cov hlwb, lub luag haujlwm rau kev tsim lub zog feem ntau ntawm tes hauv daim ntawv ntawm adenosine triphosphate (ATP). NR Chloride pab tswj kev ua haujlwm zoo mitochondrial los ntawm kev ua kom muaj kev txaus siab ntawm NAD +, uas yog qhov tseem ceeb rau cov saw hlau thauj hluav taws xob thiab ATP ntau lawm.
kho DNA
PARPs, uas sawv cev rau poly(ADP-}ribose) polymerases, yog cov piv txwv ntawm cov enzymes uas ua lub luag haujlwm ntawm cofactors rau NAD + cov proteins. Cov txheej txheem ntawm kev kho DNA no nyob ntawm qhov muaj cov enzymes no. NR Chloride tej zaum yuav muaj peev xwm pab tau hauv kev khaws cia ntawm genomic kev ncaj ncees thiab kev tiv thaiv DNA kev puas tsuaj uas cuam tshuam nrog kev laus. Qhov no yog vim qhov tseeb tias nws pab hauv kev saib xyuas ntawm NAD + qib.
Kev ua haujlwm ntawm Sirtuins
Ib tsev neeg ntawm cov proteins hu ua sirtuins yog lub luag haujlwm rau kev tswj hwm ntau yam ntawm tes, suav nrog cov metabolism, cov lus teb rau kev ntxhov siab, thiab kev ua neej ntev. Rau sirtuin ua kom tshwm sim, NAD + yog qhov tsim nyog. Ntxiv nrog NR chloride muaj peev xwm ua kom cov sirtuin kev ua si, uas tuaj yeem txhim kho cellular noj qab haus huv thiab kev ua neej nyob.
Biochemical txoj hauv kev rau kev txhawb zog
Los ntawm ntau cov txheej txheem metabolic sib txawv,nicotinamide riboside chloride(NR chloride) pab txhim kho qib zog:
NAD + txoj kev khaws cia
Muaj cov txheej txheem metabolic hu ua NAD + txoj kev khaws cia uas rov ua dua NAD + los ntawm cov tebchaw cuam tshuam nrog nws qhov kev puas tsuaj. Thaum NR Chloride nkag mus rau hauv txoj kev no, nws tau dhau los ua cov txheej txheem enzymatic uas ua rau hloov pauv ntawm NR Chloride rau NAD+. Cov txheej txheem no rov ua kom cov qib ntawm NAD + hauv lub cell.
Glycolysis thiab citric acid voj voog
Glycolysis thiab citric acid voj voog yog ob qho tseem ceeb tshaj plaws ntawm cov txheej txheem lom neeg uas ua rau kev tsim cov cellular zog. Ob qho ntawm cov dej num no tau txais kev txhawb nqa los ntawm NR Chloride, uas tseem ua rau kev saib xyuas cov qib tsim nyog ntawm NAD+. Cov kev no yog lub luag haujlwm rau kev tsim cov ATP thiab txo qhov sib npaug, uas tom qab ntawd siv rau kev tsim hluav taws xob ntau dua. Cov kev no yog qhib los ntawm kev tawg ntawm cov piam thaj thiab lwm yam khoom noj.
Oxidative phosphorylation
NR Chloride muab kev txhawb nqa tsis ncaj rau oxidative phosphorylation, uas yog theem kawg ntawm kev ua pa ntawm tes. Qhov no ua tiav los ntawm kev ua kom ntseeg tau tias muaj cov khoom txaus ntawm NAD + rau cov saw hlau thauj hluav taws xob. Cov txheej txheem tshwj xeeb no yog lub luag haujlwm rau feem ntau ntawm ATP synthesis uas tshwm sim hauv cov kab mob uas muaj aerobic.
Sib piv nrog lwm cov NAD + precursors
Nws yog ib qho tsim nyog yuav tsum muaj kev nkag siab zoo txog yuav ua li casnicotinamide riboside chloride(NR Chloride) muaj feem xyuam rau lwm cov tebchaw uas poob rau hauv pab pawg no, txawm hais tias nws yog ib qho zoo NAD + precursor:
NR Chloride vs Nicotinamide (NAM)
Niacinamide, uas yog lwm lub npe rau nicotinamide, yog ib hom vitamin B3 uas tseem yog ib qho ua ntej rau cov molecule hu ua NAD+. NAM thiab NR Chloride ob leeg muaj peev xwm nce qib NAD +; Txawm li cas los xij, NR Chloride tuaj yeem muab qee qhov zoo xws li cov hauv qab no:
- Nyob rau hauv sib piv rau ntau npaum li cas ntawm NAM, NR Chloride tsis txwv cov kev ua ntawm sirtuins.
- Muaj qhov ua tau tias NR Chloride muaj ntau dua bioavailability thiab cellular absorption.
NR Chloride vs Nicotinic Acid (NA)
Nicotinic acid, feem ntau hu ua niacin, yog ib daim ntawv ntxiv ntawm cov vitamin B3 uas muaj peev xwm nce qib ntawm NAD +. Tab sis NR Chloride tej zaum yuav muaj qee qhov zoo dua NA, suav nrog cov hauv qab no:
- NR Chloride tsis ua rau dej ntws, ib qho kev mob tshwm sim ntawm NA supplementation
- NR Chloride tuaj yeem muaj txoj hauv kev ncaj qha rau NAD + kev sib txuas
NR Chloride vs Nicotinamide Mononucleotide (NMN)
Nyob rau hauv xyoo tas los no, nicotinamide mononucleotide tau tshwm sim los ua ib qho tseem ceeb NAD + precursor uas tau txais kev txaus siab ntxiv. Txawm hais tias NR Chloride thiab NMN muaj ob qho tib si pom muaj peev xwm hais txog kev nce qib NAD +, muaj ob peb qhov sib txawv tseem ceeb ntawm ob:
- NR Chloride tej zaum yuav muaj bioavailability zoo dua vim nws qhov me me molecular
- NMN yuav tsum muaj cov kauj ruam enzymatic ntxiv kom hloov mus rau NAD +
Xaus
NR Chloride ua lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob ntawm tes thiab tau pom muaj peev xwm tiv thaiv - cov qauv kev laus. Los ntawm kev txhawb nqa NAD + qib, NR Chloride pab txhawb kev ua haujlwm mitochondrial, kho DNA, thiab ua kom sirtuin, tag nrho cov no yog qhov tseem ceeb rau kev tswj hwm cellular noj qab haus huv thiab kev sib ntaus sib tua hnub nyoog - cuam tshuam poob.
Raws li kev tshawb fawb hauv daim teb no txuas ntxiv mus, NR Chloride tseem yog ib qho kev cog lus rau cov neeg nrhiav kev txhim kho lawv lub zog ntawm tes thiab txhawb kev noj qab haus huv. Txawm li cas los xij, nws tseem ceeb heev uas yuav tsum nco ntsoov tias thaum NR Chloride qhia cov lus cog tseg, xav tau kev tshawb fawb ntxiv kom nkag siab txog nws qhov ntev - cov txiaj ntsig thiab cov tswv yim siv tshuaj kom zoo.
Rau cov tuam ntxhab thiab cov khoom lag luam hauv kev lag luam kev noj qab haus huv thiab kev noj qab haus huv tab tom nrhiav kev sib koom ua kenicotinamide riboside chloride hmoovrau hauv lawv cov khoom, koom tes nrog tus neeg muag khoom ntseeg tau yog qhov tseem ceeb. Shaanxi Yuantai Biological Technology Co., Ltd. (YTBIO) yog ib tug ua nicotinamide riboside chloride chaw tsim tshuaj paus nrog rau kev cog lus kom zoo thiab innovation. Nrog cov ntawv pov thawj suav nrog HACCP, ISO9001, ISO22000, HALAL, KOSHER, FDA, thiab EU & NOP Organic, YTBIO ua kom cov qauv siab tshaj plaws hauv cov khoom zoo thiab kev nyab xeeb.
Txawm hais tias koj yog ib lub tuam txhab nutraceutical, cov khoom noj khoom haus kev ua si, lossis cov chaw tsim khoom noj khoom haus, YTBIO tuaj yeem muab cov tshuaj zoo tshaj nicotinamide riboside chloride hmoov rau koj los tiv thaiv- kev laus thiab lub zog- txhawb kev tsim tawm. Lawv pab neeg muag khoom ua haujlwm pab cov neeg siv khoom hauv ntau dua 100 lub teb chaws thiab 500 kev lag luam, muab qhov tshwj xeeb tom qab- kev muag khoom thiab kev txhawb nqa.
Yog xav paub ntxiv txog kev koom ua ke NR Chloride rau hauv koj cov khoom thiab kom tau txais txiaj ntsig los ntawm YTBIO cov kws tshaj lij hauv cov khoom xyaw ntuj thiab cov organic, hu rau lawv ntawmsales@sxytbio.com. Ua cov kauj ruam tom ntej hauv kev hloov pauv koj cov khoom lag luam nrog kev txiav -ntug NAD + precursors thiab koom ua ntej ntawm kev kho mob ntawm tes.
Cov ntaub ntawv
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2. Trammell, SA, et al. (2016). Nicotinamide riboside yog qhov tshwj xeeb thiab qhov ncauj bioavailable nyob rau hauv nas thiab tib neeg. Kev sib txuas lus ntuj, 7(1), 1-14.
3. Cantó, C., et al. (2012). NAD + precursor nicotinamide riboside txhim kho cov metabolism hauv oxidative thiab tiv thaiv kev rog siab - noj cov rog- ntxias rog. Cell metabolism, 15(6), 838-847.
4. Martens, CR, et al. (2018). Kev noj qab haus huv nicotinamide riboside ntev yog qhov zoo- zam thiab txhawb nqa NAD+ hauv nruab nrab noj qab haus huv - cov neeg laus thiab cov laus. Kev sib txuas lus ntuj, 9(1), 1-11.
5. Yoshino, J., et al. (2018). Nicotinamide mononucleotide, ib qho tseem ceeb NAD + nruab nrab, kho cov kab mob pathophysiology ntawm kev noj haus-thiab hnub nyoog- ua rau mob ntshav qab zib hauv cov nas. Cell metabolism, 14(4), 528-536.
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