Taw qhia:
D Biotin yog yim daim ntawv ntawm cov dej-soluble vitamin, biotin, los yog vitamin B7. Nws yog ib tug coenzyme - los yog auxiliary enzyme - siv nyob rau hauv ntau yam metabolic tshua nyob rau hauv lub cev. Biotin koom nrog hauv lipid thiab protein metabolism, pab hloov zaub mov rau hauv qabzib, uas lub cev tuaj yeem siv rau lub zog. Nws tseem yog ib qho tseem ceeb rau kev tswj ntawm daim tawv nqaij, plaub hau thiab mucous daim nyias nyias.
Biotin (Biotin) yog ib qho ntawm cov vitamins B, tseem hu ua vitamin H, vitamin B7, coenzyme R (Coenzyme R) thiab lwm yam. Nws yog ib qho tseem ceeb uas tuaj yeem tiv thaiv cov plaub hau thiab tawv nqaij puas tsuaj hauv cov nas vim yog noj cov qe nqaij nyoos los ntawm lub siab thaum kawm cov poov xab loj hlob thiab rhizobia kev loj hlob thiab kev ua pa txhawb nqa hauv xyoo 1930s. Biotin yog ib tug tswv cuab ntawm cov dej-soluble vitamin B pawg. Nws muaj ntau dua hauv daim siab, raum, poov xab, thiab mis nyuj, thiab yog ib qho tseem ceeb rau cov kab mob los kho cov pa roj carbon dioxide. Nws yog ib qho yooj yim los ua ke nrog cov protein hauv qe dawb. Kev noj cov protein ntau tuaj yeem cuam tshuam kev nqus ntawm biotin thiab ua rau biotin tsis txaus, xws li cov plaub hau poob, poob phaus, dermatitis, thiab lwm yam. Biotin plays lub luag haujlwm tseem ceeb hauv biochemical cov txheej txheem xws li roj synthesis thiab gluconeogenesis.
Biotin yog tus cawm seej ntawm cov neeg khaus. Nws tsis tsuas yog tiv thaiv cov plaub hau poob thiab lub teeb rau saum lub taub hau, tab sis kuj tiv thaiv cov plaub hau grey ntawm cov neeg niaj hnub no. Nws kuj tseem ua lub luag haujlwm tseem ceeb hauv kev saib xyuas ntawm daim tawv nqaij. Raws li rau cov nyhuv ntawm stabilizing lub paj hlwb, nws tsis tau lees paub, tab sis nws yog qhov tseeb pab rau kev nyuaj siab thiab insomnia.
Biotin yog coenzyme ntawm ntau yam carboxylase thiab ua raws li CO2 cab kuj nyob rau hauv cov tshuaj tiv thaiv carboxylase.
Physiological muaj nuj nqi:
Tib neeg lub cev xav tau txog 100-300 micrograms ib hnub. Muaj cov tshuaj tiv thaiv biotin hauv cov qe dawb uas tuaj yeem ua ke nrog biotin, thiab cov biotin ua ke tsis tuaj yeem nqus tau los ntawm txoj hnyuv; ua rau tsis muaj biotin nyob rau hauv cov tsiaj, lub sij hawm no, tsis qab los noj mov, glossitis, dandruff dermatitis, plaub hau tsis tos. Txawm li cas los xij, tsis muaj qhov tshwm sim ntawm biotin deficiency hauv tib neeg tau pom, tej zaum vim yog kev sib txuas ntawm biotin los ntawm cov kab mob plab ntxiv rau cov khoom noj. Biotin yog ib tug coenzyme ntawm ntau yam enzymes nyob rau hauv tib neeg lub cev, koom nyob rau hauv lub metabolism ntawm fatty acids thiab carbohydrates nyob rau hauv lub cev; txhawb nqa protein synthesis; kuj koom nrog hauv cov metabolism ntawm vitamin B12, folic acid, thiab pantothenic acid; txhawb cov synthesis thiab excretion ntawm urea.
① Pab lub cev synthesis thiab metabolism ntawm cov rog, glycogen thiab amino acid nyob rau hauv tib neeg lub cev;
② Txhawb nqa kev ua haujlwm ib txwm muaj thiab kev loj hlob ntawm cov qog hws, paj hlwb, pob txha pob txha, txiv neej gonads, tawv nqaij thiab plaub hau, thiab txo cov tsos mob ntawm eczema thiab dermatitis;
③ Tiv thaiv cov plaub hau grey thiab plaub hau poob, pab kho qhov tawv nqaij;
④ yooj yim mob leeg;
⑤ Txhawb nqa urea synthesis thiab excretion, purine synthesis thiab biosynthesis ntawm oleic acid.
⑥Rau kev kho mob arteriosclerosis, mob stroke, lipid metabolism tsis zoo, kub siab, kab mob plawv thiab ntshav ncig.
Cov tsos mob ntawm Biotin deficiency:
Biotin, tseem hu ua vitamin H thiab coenzyme R, muaj lub nplhaib ureido thiab lub nplhaib thiophene nrog valeric acid sab saw. Nws muaj 8 isomers, tsuas yog ib qho biotin tshwm sim, thiab nws muaj kev ua haujlwm lom neeg. Biotin hauv lub cev feem ntau khaws cia hauv daim siab, thiab nws cov concentration yog 800-3000ng / g. Cov ntshav cov ntsiab lus tsawg. Nws lub luag haujlwm tseem ceeb yog ua raws li coenzyme hauv decarboxylation-carboxylation cov tshuaj tiv thaiv thiab cov tshuaj tiv thaiv deamination
Daim ntawv thov:
Biotin yog ib qho tseem ceeb coenzyme hauv carbohydrate, rog thiab protein metabolism. Koom tes hauv kev sib koom ua ke ntawm cov carbohydrates thiab cov protein, thiab hloov pauv cov protein thiab carbohydrates rau hauv rog. Thiab ua ib coenzyme ntawm carboxylase, hloov carboxyl thiab kho carbon dioxide. Nws kuj yog siv los ua ib pab pawg neeg prosthetic rau ntau cov enzymes thiab ua raws li cov cab kuj carboxyl. Hauv cov metabolism hauv carbohydrate, nws kho cov pa roj carbon dioxide thiab decarboxylates. Biotin koom nrog hauv cov txheej txheem metabolic ntawm qab zib, protein thiab rog hauv daim ntawv ntawm coenzyme hauv cov tsiaj. Biotin yog qhov tsim nyog los tswj kev loj hlob ntawm cov tsiaj tawv nqaij, plaub hau, hooves, kev loj hlob thiab paj hlwb, thiab tseem tuaj yeem txhim kho kev siv khoom noj thiab qhov hnyav nce. Thaum nws tsis muaj, kev loj hlob qeeb, kev loj hlob tsis zoo, dermatitis, plaub hau poob, tawv nqaij keratosis, thiab lwm yam tshwm sim. Npua feem ntau muaj daim tawv nqaij rwj, o ntawm lub qhov ncauj mucosa, raws plab, convulsions, tawg thiab los ntshav ntawm cov pob qij txha. Nws yog tsuas yog siv los ua ib qho adjuvant rau cov kab mob tshwm sim los ntawm vitamin H tsis txaus thiab noj tsis txaus.
nyhuv
1. Koom nrog cov metabolism hauv fatty acids thiab carbohydrates nyob rau hauv lub cev, thiab yog ib tug coenzyme ntawm ntau yam enzymes.
2. Txhawb nqa protein synthesis, urea synthesis thiab excretion.
3. Txhim kho cov kev cai ntawm cov ntshav qab zib, uas muaj txiaj ntsig zoo rau kev noj qab haus huv thiab rov tsim cov hlwb.
Kev daws teeb meem:
Cov txheej txheem synthesis siv fumaric acid raws li cov khoom pib, thiab los ntawm bromine ntxiv, dibromo: compound yog hloov los ntawm benzylamine thiab phosgene nplhaib-kaw los tsim imidazolidinone maleic acid, uas yog tom qab ntawd hloov mus rau hauv cov kua qaub anhydride thiab lub nplhaib-qhib los ntawm cyclohexanol rau daim ntawv. ib qho exo Racemic monoesters raug daws rau hauv qhov xav tau optical isomers nyob rau hauv high yields nrog ephedrine, thiab cov enantiomers yog recycled rov qab mus rau lub anhydride. Cov ester daim ntawv cog lus hauv lithium borohydride txo qis ua rau nws mus rau hauv cov dej cawv hydroxyl pab pawg thiab hloov mus rau hauv lactone ntawm qhov xav tau kev teeb tsa, uas tau kho nrog potassium thioacetate los tsim thiolactone, thiab tom qab ntawd dhau los ua Grignard cov tshuaj tiv thaiv thiab lub cev qhuav dej kom tau txais thiolactone hauv sab saw. nruab nrab carbon atoms. Catalytic hydrogenation saturates sab saw ethylenic daim ntawv cog lus thiab stereospecifically tsim lub thib peb chiral centre, thiab kho nws nrog hydrobromic acid los ua ib tug cyclic sulfonium ntsev, thiab siv tus nqi-absorbing khoom ntawm sulfonium cation los qhia rau hauv nws nyob ib sab carbon atom malonate residues rau. muab biotin precursors. Thaum kawg, tom qab acidic hydrolysis, benzyl pab pawg siv los tiv thaiv ob pawg amino pawg raug tshem tawm, thiab cov malonate hloov mus rau hauv diacid thiab decarboxylated kom tau txais optically ntshiab biotin. Tag nrho cov txiaj ntsig ntawm tag nrho cov txheej txheem yog ntau dua 25 feem pua, thiab qhov nruab nrab tawm los ntawm txhua kauj ruam yog tshaj 90 feem pua.
