Geniposide yog dab tsi?
Geniposide tseem hu ua gardeniposide.Geniposide yog ib qho organic compound nrog cov mis mos molecular C17H24O10. Cov khoom no tau muab rho tawm thiab ua kom zoo los ntawm cov txiv hmab txiv ntoo qhuav thiab paub tab ntawm Rubiaceae cog Gardenia siv cov cuab yeej siv high-tech. Geniposide yog ib qho iridoid glycoside compound. Cov khoom ntshiab yog hmoov dawb nrog ib qho kev sib hloov [ ]D20+7.5 degree (dej). Yooj yim soluble hauv dej, soluble hauv ethanol, insoluble hauv roj av ether. Gardenia glycoside muaj ntau yam siv. Fermentation nyob rau hauv txawv tej yam kev mob yuav ua tau rau hauv tej yam ntuj tso edible colorants gardenia xiav thiab gardenia liab. Nws tseem yog ib qho khoom siv raw khoom siv los kho cov hlab plawv, cerebrovascular, hepatobiliary thiab lwm yam kab mob nrog rau ntshav qab zib.
Kev ua haujlwm ntawm Geniposide
Geniposide muaj cov teebmeem ntawm laxative, analgesic, choleretic, anti-inflammatory, kho cov nqaij mos raug mob, inhibiting gastric kua secretion thiab txo cov pancreatic amylase.
1. Cov nyhuv choleretic:Geniposide muaj qhov pom tseeb ntawm lub zais zis contraction, thiab nws cov nyhuv contraction yog ntau dua li cov dej, txawm tias ze rau cov nyhuv ntawm cov rog rog. Yog li ntawd, gardenia ntseeg tau tias muaj cov nyhuv choleretic thiab tshem tawm pob zeb.
2.Hepatoprotective nyhuv:Cov ursolic acid muaj nyob rau hauv gardenia tuaj yeem txo cov ntshav aminotransferase thiab muaj kev cuam tshuam tseem ceeb rau cov qog nqaij hlav cancer hauv lub siab.
3.Anti-thrombotic nyhuv:Kev txhaws ntawm endothelial cell loj hlob tom qab vascular raug mob tuaj yeem ua rau atherosclerosis thiab thrombosis. Geniposide tuaj yeem txhawb txoj kev loj hlob ntawm cov txheej txheem protofibroblast kev loj hlob thiab yog cov khoom siv zoo hauv kev tiv thaiv atherosclerosis thiab tiv thaiv thrombosis.
4.Anti-inflammatory nyhuv:Gardenia ethyl acetate extract thiab 90% ethanol extract tuaj yeem cuam tshuam o los ntawm xylene thiab o los ntawm formaldehyde. Qhov no cais tawm muaj kev kho mob rau congestion thiab hemorrhagic raug mob.
Daim ntawv thov
Gardenia los ntawm cov txiv hmab txiv ntoo qhuav thiab paub tab ntawm Rubiaceae cog Gardenia jasminoides Ellis. Gardenia muaj ntau tshaj 40 physiologically active tshuaj, ntawm cov khoom xyaw nquag ntawm gardenia, ib txwm suav tshuaj lees paub hauv tsev thiab txawv teb chaws, yog iridoids. Cov iridoids muaj nyob rau hauv gardenia muaj xws li gardeniposide, geniposide, hydroxygeniposide, geniposide, thiab lwm yam. Ntawm lawv, cov khoom xyaw nquag tshaj plaws yog gardeniposide thiab geniposide. Gardenia glycoside yog ib qho nruab nrab hauv kev tsim tawm ntawm gardenia xiav, gardenia liab, thiab gardenia violet thiab ib qho zoo monomer rau cov tshuaj crude. Yog li ntawd, kev sib cais, purification, crystallization thiab cov ntsiab lus txiav txim siab ntawm gardeniaside tau dhau los ua cov thev naus laus zis tseem ceeb rau kev loj hlob ntawm gardenia. Kev sib cais ntawm geniposide tuaj yeem ua tiav ib txhij nrog kev sib cais ntawm -crocin. Txoj kev paub tab ntau dua yog siv macroporous resin adsorption thiab desorption technology. Feem ntau ntawm cov resins xaiv tsis muaj zog polar thiab tsis-polar, xws li HP20, XAD22, HPD2100, X25, NKA, thiab lwm yam. Cov ntaub ntawv qhia tias cov purification txoj kev ntawm gardeniposide feem ntau muaj xws li: lead ntsev los nag txoj kev, activated carbon impurity tshem tawm txoj kev, silica gel adsorption txoj kev, thiab lwm yam. Cov lus xaus ua ntej kos los ntawm kev sib piv txoj kev tshawb fawb yog tias cov qauv saum toj no tau txais kev tshawb fawb, tab sis tsis tuaj yeem siv rau kev tsim khoom. Cov teeb meem tseem ceeb yog: cov txheej txheem nyuaj, kev siv cov khoom siv ntau dhau, tsis tshua muaj txiaj ntsig, thiab siv ntau cov tshuaj lom thiab tsim kev puas tsuaj, xws li ether, chloroform, methanol, acetone, lead ntsev, thiab lwm yam. Tsis ua raws li cov khoom noj thiab tshuaj ntau lawm. Lub hom phiaj ntawm purifying gardeniposide tuaj yeem ua tiav los ntawm kev siv kem chromatography. Los ntawm kev xaiv kev nyab xeeb, tsis muaj tshuaj lom, tsim nyog nyob ruaj ruaj thiab theem mobile, nyob rau hauv qee qhov muaj peev xwm adsorption, kub, pH, txaus tus nqi, txaus tus nqi thiab lwm yam kev mob, cov ntsiab lus ntawm gardeniposide tuaj yeem ua kom huv huv ntawm 50% txog 95%. Tsim cov xwm txheej tsim nyog rau crystallization ntawm gardeniposide. Cov txheej txheem rau kev ntsuas cov ntsiab lus ntawm gardeniposide muaj xws li nyias txheej ultraviolet txoj kev, nyias-txheej scanning method, high-performance kua chromatography, thiab lwm yam. Cov txheej txheem nyias txheej ultraviolet thiab nyias txheej scanning txoj kev tsis yog heev, thiab high-zoo Txoj kev ua kua chromatography yog qhov tseeb rau gardeniposide. , txoj kev txiav txim siab ceev ceev, thiab kev tsim cov qauv zoo.
Txoj kev Extraction thiab sib cais
Tam sim no, cov txheej txheem tseem ceeb ntawm kev sib cais gardeniposide los ntawm gardenia muaj xws li macroporous adsorption resin method, ion exchange resin method, ob-theem aqueous system method, silica gel kem chromatography, organic solvent crystallization method, thiab lwm yam. loj-scale industrial ntau lawm.
Tus Txheej Txheem Kev Txiav Txim Siab
1.Kev ua haujlwm siab ua kua chromatography: Gardeniposide yog ib qho iridoid glycoside compound, uas yog hydrophilic. Cov theem ntawm lub xov tooj ntawm tes yog feem ntau aqueous phosphate daws thiab polar solvents.
2.Thin-layer scanning method: Geniposide muaj fluorescence absorption me ntsis ntawm 254 nm hauv cheeb tsam ultraviolet. Ua kom zoo dua ntawm cov yam ntxwv no, nws tau muab tso rau hauv lub teeb fluorescent thiab luam tawm hauv cheeb tsam ultraviolet. Cov txheej txheem yog qhov yooj yim thiab yooj yim rau kev siv, nrog rau qhov chaw ruaj khov thiab zoo rov ua dua tshiab.
3.Thin-layer-UV spectrophotometry: siv 0.3% CMC-Na silica gel GF254 nyias-txheej phaj, tsim tus neeg sawv cev: chloroform-methanol (3: 1), ntsuas wavelength 237 nm. Kev npaj ntawm kev sim tshuaj: Precisely hnyav 2 g ntawm gardenia soothing tshuaj yej hmoov, ntxiv dej thiab boil rau 30 feeb, lim, ntxiv 1% gelatin mus rau lub filtrate, do kom huv si, centrifuge, coj lub supernatant, thiab extract nrog n-butanol Peb lub sij hawm, 30 mL txhua lub sij hawm, muab cov n-butanol daws, lub cev qhuav dej nrog anhydrous calcium chloride, evaporate rau qhuav nyob rau hauv ib da dej, yaj nrog methanol thiab hloov mus rau 10 mL ntsuas lub hwj, dilute rau lub cim nrog methanol, thiab tau txais nws. .
Kev cia siab ntawm kev ua lag luam
Gardenia yog ib hom tshuaj suav tshuaj hauv Suav teb nrog ntau yam kev siv, thiab nws cov ntaub ntawv tshawb fawb txog kev lag luam tau nce xyoo los ntawm xyoo. Nrog rau kev tshawb fawb tob zuj zus ntawm cov tshuaj ntuj, kev siv tshiab ntawm gardeniposide yuav raug tshawb pom, thiab cov txheej txheem ntawm nws cov tshuaj pharmacological yuav ua kom pom tseeb. Kev kho mob thiab kev lag luam thov kev cia siab ntawm gardeniposide yuav dhau los ua ntau dua.
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