Poria cocos extract yog dab tsi
Poria cocos extract yog muab los ntawm qhuav sclerotia ntawm Polyporaceae fungus Poria cocos. Poria cocos yog ib qho kab mob txhua xyoo lossis perennial fungus. Cov npe qub yog Fu Ling thiab Fu Luav. Kuj hu ua Pine qos yaj ywm, Pine qos yaj ywm, Pine qos yaj ywm, thiab lwm yam. Cov sclerotia yog siv los ua tshuaj. Poria cocos extract tsuas yog muaj triterpenes thiab polysaccharides, uas muaj cov teebmeem ntawm ntxiv dag zog rau tus po, calming cov hlab ntsha, diuresis, thiab tshem tawm dampness. Nws yog siv los kho tus po tsis txaus, tsis muaj zaub mov, edema thiab oliguria. Kev tshawb fawb tshuaj niaj hnub no qhia tau hais tias Poria cocos muaj ntau yam tshuaj siv tshuaj, xws li inhibiting kev loj hlob ntawm tus kab mob spleen thiab txhim kho lub cev tiv thaiv kab mob.
Pharmacological teebmeem ntawm Poria cocos extract
1. Immunomodulation
Lub immunomodulatory muaj nuj nqi ntawm Poria cocos yog tam sim no feem ntau lees paub muaj nuj nqi, thiab muaj ntau yam kev tshawb fawb ntawm no nam. Los ntawm cov khoom xyaw ntawm Poria cocos extract, T thiab B lymphocyte proliferation qauv tau siv los ua lub chaw soj ntsuam, thiab lymphocytes tau siv los ua lub hom phiaj. Txoj kev tshawb pom ntawm tes siv tau los txiav txim seb qhov muaj sia nyob ntawm tes, thiab cov khoom xyaw nrog immunomodulatory kev ua haujlwm raug kuaj xyuas, thiab Poria cocos polysaccharide tau txiav txim siab. Cov khoom lag luam degradation, carboxymethylated derivatives thiab Poria cocos ethyl acetate extract yog cov khoom siv tseem ceeb. Kev txheeb xyuas ntxiv thiab kev tshawb fawb txog kev tiv thaiv kab mob tau pom tias plaub lub tebchaw suav nrog tuckahoe acid muaj kev tiv thaiv kab mob lom. Yuav ua li cas txhim kho lub cev tiv thaiv kab mob kev ua haujlwm ntawm Poria kuj yog ib qho ntawm kev tshawb fawb tam sim no. Cov ntsiab lus ntawm cov dej-soluble polysaccharides nyob rau hauv Poria cocos extract yog tsawg, uas imposes tej yam kev txwv rau nws lom functions. Yog li ntawd, Poria cocos polysaccharides raug hloov kho cov qauv, xws li carboxymethylation, sulfate esterification, hydroxypropylation, thiab hydroxyethyl. Los ntawm chemicalization, methylation, thiab lwm yam., ntau yam derivatives ntawm Poria polysaccharide tuaj yeem tau txais, uas txhim kho nws cov dej solubility thiab kev lom zem rau ntau qib.
2. Anti-inflammatory thiab anti-inflammatory
Poria cocos extract muaj cov tshuaj tiv thaiv zoo rau ntau hom mob. Feem ntau cov kev tshawb fawb tau pom tias triterpenoids hauv Poria cocos yog cov khoom tseem ceeb ntawm cov tshuaj tiv thaiv kab mob. Lawv ua tiav los tiv thaiv kev mob los ntawm inhibiting phospholipase (PLA2). nyhuv. Qee cov kev tshawb fawb kuj ntseeg tias Poria cocos polysaccharide kuj muaj qee yam kev tiv thaiv kab mob.
3. Antioxidant
Cov nyhuv antioxidant ntawm Poria tsis ntev los no tau txais kev saib xyuas ntau dua. Oxidation muaj feem xyuam rau ntau yam kab mob, xws li qog nqaij hlav, o, txo kev tiv thaiv kab mob, thiab lwm yam. Yog li ntawd, cov nyhuv antioxidant yuav yog ib qho ntawm cov txheej txheem ntawm lwm yam haujlwm ntawm Poria. Cov triterpenoids hauv Poria cocos extract tuaj yeem tshem tawm cov superoxide anion radicals (O2-), hydroxyl radicals (·OH) thiab hydrogen peroxide (H2O2), thiab tus nqi khawb muaj kev sib raug zoo ntawm koob tshuaj nrog rau cov concentration ntau; Ntxiv rau hauv vitro Antioxidant thwmsim qhia tias Poria cocos triterpenoids tuaj yeem cuam tshuam cov hemolysis ntawm cov qe ntshav liab thiab muaj cov txiaj ntsig zoo ntawm malondialdehyde (MDA) tsim los ntawm nas lub siab lipid peroxidation. Ntxiv nrog rau triterpenoids, Poria cocos polysaccharides kuj tau pom tias muaj cov haujlwm antioxidant. Poria cocos feem ntau siv ua ke nrog cov tshuaj tiv thaiv kab mob hauv cov tshuaj suav tshuaj. Cov kua txiv hmab txiv ntoo ntawm Poria cocos thiab qee yam ntawm nws cov purified Cheebtsam tau hais lus rau tus qauv nas ntawm hom 2 mob ntshav qab zib. Cov kua txiv hmab txiv ntoo ntawm Poria cocos thiab triterpenoids tuaj yeem txo cov ntshav qab zib los ntawm kev txhim kho cov tshuaj insulin.
4. cuam tshuam rau kev tso zis
Cov tshuaj suav tshuaj suav hais tias Poria cocos tuaj yeem diuretic thiab dampness, thiab tuaj yeem kho cov tsos mob xws li tso zis nyuaj thiab o thiab puv. Cov kev tshawb fawb niaj hnub no qhia tau hais tias qhov no feem ntau cuam tshuam nrog Poria cocos polysaccharide, thiab nws muaj qee yam cuam tshuam rau nephritis, kab mob prostate, thiab lwm yam. Raws li thaum ntxov xyoo 1990, nws tau pom tias Poria polysaccharide muaj cov nyhuv inhibitory ntawm glomerulonephritis hauv nas, feem ntau yog inhibiting. C3 deposition nyob rau hauv lub glomerulus. Pachymic acid (PA) raug cais los ntawm Poria cocos thiab nws cov nyhuv ntawm tib neeg prostate qog hlwb tau kawm. Nws tau pom tias PA tuaj yeem ua rau qeeb zuj zus ntawm cov qog hlwb thiab ua rau cov cell apoptosis. Cov kev tshawb fawb ntxiv pom tias PA inhibits prostaglandins. Kev tsim khoom thiab kev ua AKT raug txo qis, ua rau cov cell apoptosis. Ib txoj kev tshawb fawb tsis ntev los no tau tshuaj xyuas cov nyhuv inhibitory ntawm Poria cocos ntawm kev qhia ntawm cov dej channel AQP2 vim yog siab osmotic siab hauv lub raum. Cov txiaj ntsig tau pom tias Poria cocos tuaj yeem ua rau muaj kev hloov pauv thiab nthuav tawm ntawm nws cov mRNA thiab cov protein, qhia tias Poria cocos tuaj yeem tswj cov dej tshuav ntawm lub raum hlwb hauv qab osmotic siab. , thiab inhibit cell apoptosis nyob rau hauv siab osmotic siab, uas piav qhia txog cov nyhuv ntawm cov tshuaj tsoos Poria ntawm cov zis los ntawm ib txoj kev xav molecular.
Extraction txheej txheem ntawm Poria cocos extract
Kev rho tawm ntawm Poria polysaccharides: Poria polysaccharides suav nrog dej-soluble thiab alkali-soluble polysaccharides. Kev lig kev cai, dej kub extraction thiab dilute alkali extraction yog siv feem. Cov txheej txheem ntws ntawm txoj kev rho tawm yog feem ntau: Poria cocos crushing, degreasing, extraction centrifugation, supernatant concentration, cawv nag lossis daus, impurity tshem tawm, thiab ziab. Txawm li cas los xij, polysaccharide extraction tus nqi ntawm cov dej extraction yog tsawg, thiab cov dilute alkali leaching txoj kev yooj yim inhibits kev lom ntawm Poria cocos polysaccharide. Tam sim no, cov thev naus laus zis tshiab feem ntau siv los pab tshem tawm, xws li ultrasound, microwave, txoj kev enzymatic, thiab lwm yam, los yog kev sib xyaw ntawm ntau yam thev naus laus zis los txhim kho cov txiaj ntsig polysaccharide.
2. Extraction ntawm triterpenoids: Muaj ntau ntau hom triterpenoids hauv Poria cocos, tab sis lawv cov ntsiab lus kuj me me. Tam sim no tsis muaj cov ntaub ntawv teev tseg ntawm cov ntsiab lus ntawm triterpenoids hauv Poria cocos, tab sis muaj cov ntaub ntawv qhia txog kev rho tawm triterpenoid los ntawm cov ntaub ntawv. Kev txiav txim los ntawm qhov sib piv, nws yuav tsum tsuas yog kwv yees li 1% mus rau 2% ntawm qhov hnyav qhuav ntawm Poria cocos. Vim yog cov yam ntxwv ntawm triterpenoids, cov kuab tshuaj organic feem ntau siv rau kev rho tawm. Lub ntsiab extraction txheej txheem yog: crushing-organic hnyav reflux extraction-concentration. Txoj kev siv ntau tshaj plaws yog siv methanol los yog 95% ethanol rau reflux extraction, ua raws li rotary evaporation los yog dej nag lossis daus. Cov khoom tau txais raws li cov kauj ruam saum toj no yog crude triterpene extract. Cov kua txiv hmab txiv ntoo kuj tseem tuaj yeem ua kom huv ntxiv, xws li rov ua dua nrog chloroform lossis rho tawm nrog ethyl acetate. Organic solvent extraction feem ntau tuaj yeem rho tawm feem ntau triterpenoids, nrog rau cov txiaj ntsig txog li 95%. Kuj tseem muaj qee qhov kev tshawb fawb siv lwm txoj kev pabcuam xws li supercritical CO2 rho tawm. Raws li cov txheej txheem, tus nqi rho tawm ntawm tag nrho cov triterpenoid tebchaw yog 2.06%, thaum lub extraction tus nqi ntawm tag nrho cov triterpene tebchaw los ntawm cov organic solvent extraction method yog 1.39%, thiab cov extraction tus nqi yog 48.2% siab dua.
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