Taw qhia
Sodium hyaluronatenws tus kheej yog ib qho ntawm cov khoom ntawm tib neeg cov tawv nqaij, yog qhov dav tshaj plaws ntawm acidic nplaum qab zib hauv tib neeg lub cev, muaj nyob hauv matrix ntawm cov ntaub so ntswg sib txuas, muaj cov nyhuv moisturizing zoo. Nws yog ib hom kab mucopolysaccharide nrog siab molecular loj, uas yog polymerized los ntawm disaccharide chav tsev ntawm glucuronic acid thiab acetyl aminohexose. Nws qhov hnyav molecular yog 1 lab. Tsim cov kua viscoelastic tuab hauv dej nrog lub cev pH thiab lub zog ionic.
Kev lag luam hyaluronic acid yog nws daim ntawv ntsev ntsev, uas yog sodium hyaluronate (SH luv luv). Nws yog ib qho dawb fiber ntau los yog hmoov hmoov, muaj zog hygroscopic zog, soluble hauv dej, insoluble hauv cawv, ketone, ether thiab lwm yam organic solvents. Nws cov tshuaj aqueous yog tsis zoo them thiab muaj viscoelasticity siab thiab osmotic siab ntawm siab concentrations.
HA yog yooj yim decomposed los ntawm acid, alkali los yog kev kho cua sov; Nyob rau hauv lub xub ntiag ntawm hlau ions xws li hlau thiab tooj liab thiab txo cov neeg sawv cev xws li ascorbic acid los yog cysteine, nws yuav degraded los ntawm oxygen dawb radicals, χ-ray, -ray, ultraviolet rays thiab ultrasonic yoj. Nws tseem tuaj yeem tawg los ntawm hyaluronidase thiab chondroitin sulfate. Lub siab molecular hnyav HA tuaj yeem txo qis rau qhov hnyav molecular nyob rau hauv cov xwm txheej ntawm cov enzymes, acids, cua sov, thiab lwm yam. Tsis tas li ntawd, HA aqueous tov yog cov kua tsis-Newtonian nrog zoo viscoelasticity thiab ntws deformation. Raws li cov khoom tshwj xeeb ntawm HA, HA tuaj yeem siv dav hauv tshuaj, tshuaj pleev ib ce thiab zaub mov noj. HA feem ntau yog siv rau hauv kev kho mob, kuaj mob, tshuaj pleev ib ce thiab khoom noj khoom haus thiab kev noj qab haus huv.
Muaj nuj nqi
Tiv thaiv articular pob txha mos
Sodium hyaluronate yog cov khoom tseem ceeb ntawm cov kua dej synovial thiab yog ib qho ntawm cov pob txha mos matrix. Nws ua lub luag haujlwm lubricating hauv kev sib koom ua ke, tuaj yeem txo qhov kev sib txhuam ntawm cov ntaub so ntswg, thiab ua si nws lub luag haujlwm elastic, tsis cuam tshuam cov kev ntxhov siab ntawm cov pob txha mos, thiab ua si nws txoj haujlwm ntawm lub cev. Sodium hyaluronate nrog siab concentration, siab viscosity thiab elasticity tuaj yeem txhim kho cov lus teb ntawm cov pob qij txha, txhim kho cov viscosity thiab lubrication muaj nuj nqi ntawm cov kua dej sib koom, tiv thaiv cov pob txha pob txha, txhawb kev kho thiab rov tsim cov pob txha pob txha, txo qhov mob thiab nce kev sib koom tes.
Txhawb kev kho qhov txhab
Sodium hyaluronate tuaj yeem txhawb kev kho qhov txhab. Sodium hyaluronate tuaj yeem tsim cov macromolecular mesh barrier rau ntawm qhov chaw ntawm lub qhov muag cov ntaub so ntswg, tiv thaiv cov tshuaj inflammatory los ntawm nkag mus rau hauv lub qhov txhab thiab qhov chaw ntawm qhov txhab, thiab txhim kho cov viscosity thiab adhesion ntawm cov tshuaj, thiaj li hais tias cov tshuaj yuav nyob twj ywm rau ntawm qhov chaw. lub cornea rau lub sij hawm ntev thiab mloog zoo, thiaj li mus cuag ib tug ntev lub sij hawm thiab haib nyhuv.
Kho qhov muag qhuav thiab lwm yam tsos mob
Sodium hyaluronate tuaj yeem ua kom cov kua muag ruaj khov, ua kom lub sijhawm tsim kua muag, thiab txo cov tsos mob ntawm qhov muag qhuav. Rau keratitis, corneal ulcer, corneal raug mob los yog lwm yam chemical thiab lub cev yam tshwm sim los ntawm pob txha kub kub.
Replenish daim tawv nqaij noo noo
hyaluronic acid ntawm daim tawv nqaij pib poob tom qab hnub nyoog 25 xyoos, thiab cov dej noo ntawm daim tawv nqaij kuj tseem yuav poob nrog hyaluronic acid, poob elasticity thiab luster, thiab cov laus tshwm sim ntawm wrinkles yuav tshwm nyob rau hauv ntev. Kev siv cov tshuaj pleev ib ce uas muaj hyaluronic acid tuaj yeem ua lub luag haujlwm hauv kev ntxiv thiab khaws cia ntawm daim tawv nqaij noo noo, rov ua dua thiab tswj cov tawv nqaij hluas dua.
Kho daim tawv nqaij puas
Tom qab ntawm daim tawv nqaij raug tshav ntuj, ultraviolet rays nyob rau hauv lub hnub tuaj yeem ua rau erythema, dermatitis, tev thiab lwm yam tshwm sim los ntawm daim tawv nqaij kub hnyiab. Sodium hyaluronate tuaj yeem txhawb kev tsim kho ntawm daim tawv nqaij hauv qhov raug mob los ntawm kev txhawb nqa kev loj hlob thiab kev faib tawm ntawm cov hlwb epidermal, thiab tshem tawm cov pa dawb radicals. Tom qab txhuam cov kua qaub, daim tawv nqaij yuav dehydrated, rhiab thiab tawg. Kev siv cov tshuaj pleev ib ce ua haujlwm yuav ua rau tawv nqaij rhiab heev. Hyaluronic acid tuaj yeem ua rau daim tawv nqaij hydrate sai, yog li koj tuaj yeem xaiv hyaluronic acid ntawm daim tawv nqaij tom qab txhuam hniav. Sodium hyaluronate muaj viscosity siab hauv cov tshuaj aqueous, thiab nws 1% aqueous tov yog gel-zoo li, uas tuaj yeem ua lub luag haujlwm thickening thiab stabilizing hauv tshuaj pleev ib ce.
Daim ntawv thov
Clinic kho qhov muag
Hyaluronic acid yog dav muaj nyob rau hauv cov tsiaj thiab tib neeg physiologically active tshuaj, thiab yog faib nyob rau hauv tib neeg daim tawv nqaij, sib koom synovial kua, umbilical qaum, aqueous lom zem thiab ocular vitreous lub cev. Nws cov tshuaj muaj viscoelasticity siab thiab cov duab luam tawm, thiab yog tus neeg sawv cev pabcuam rau kev phais ophthalmic. Tom qab txhaj rau hauv lub anterior chamber, cov tshuaj muaj peev xwm tswj tau ib tug tej yam tob ntawm lub anterior chamber, pab txoj kev phais, tiv thaiv lub corneal endothelial hlwb thiab intraocular cov ntaub so ntswg, txo cov mob phais, thiab txhawb lub qhov txhab.
Cov khoom siv tshuaj pleev ib ce
Sodium hyaline ntawv hauv cov tshuaj pleev ib ce tuaj yeem ua lub luag haujlwm hauv kev ntxiv thiab khaws cov tawv nqaij noo noo, rov ua dua thiab tswj cov tawv nqaij hluas dua. Los ntawm kev txhawb nqa kev loj hlob thiab kev faib tawm ntawm cov hlwb epidermal, nrog rau kev tshem tawm cov pa dawb radicals, nws tuaj yeem txhawb kev tsim kho ntawm daim tawv nqaij ntawm qhov raug mob, thiab siv los kho cov tawv nqaij puas. Sodium hyaluronate muaj viscosity siab hauv cov tshuaj aqueous, thiab nws 1% aqueous tov yog gel-zoo li, uas tuaj yeem ua lub luag haujlwm thickening thiab stabilizing hauv tshuaj pleev ib ce.
Kho mob caj dab
Sodium hyaluronate nrog siab concentration thiab siab viscoelasticity hauv cov kab noj hniav sib koom ua ke tuaj yeem txhim kho cov lus teb ntawm cov pob qij txha, txhim kho cov viscosity thiab lubrication muaj nuj nqi ntawm cov kua dej sib koom ua ke, txhawb kev kho thiab rov tsim kho pob txha pob txha, txo qhov mob, thiab nce kev sib koom tes. Yog li ntawd, nws tuaj yeem siv los kho degenerative osteoarthritis, mob caj dab ntev, mob caj dab lossis mob rheumatoid, mob caj dab temporomandibular, aseptic necrosis ntawm lub taub hau femoral, thiab lwm yam.
Txoj kev tsim khoom
Tom qab ntxuav 10kg ntawm cov nqaij qaib tshiab, txiav lawv finely, ntxiv ob zaug ntawm sodium hydroxide tov (2.2 → 1000), do thiab sib tov ntawm 60 degree rau 30min, ces neutralize nrog trichloroacetic acid tov, thiab ntxiv concentrated catalase rau decompose cov seem. hydrogen peroxide rau 2 teev. Tom qab ntawd cov protein tau deproteinized nrog trichloroacetic acid kom cov concentration ntawm trichloroacetic acid nyob rau hauv lub extract 5%. Tom qab pom, nws tau neutralized nrog dilute sodium hydroxide test tov. Tom qab dialysis nyob rau hauv khiav dej thaum hmo ntuj, nws tau lim. Txog 15L ntawm cov lim tau tau, thiab tom qab cua sov thiab ua kom tsis muaj menyuam, kwv yees li 45L ntawm anhydrous ethanol tau ntxiv, thiab cov nag lossis daus tau yaj nrog dej ua kom zoo, thiab tom qab ntawd tshuaj tsuag qhuav lossis khov-qhuav rau hauv cov hmoov.
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