Taw qhia
Dioscin yog qhov tseem ceeb ntawm cov nroj tsuag hauv tsev neeg Dioscoreaceae. Turmeric thiab yam, ob tus tswv cuab ntawm tsev neeg Dioscoreaceae, yog ob qhov chaw tseem ceeb ntawm diosgenin.
Cov tshuaj suav tshuaj suav hais tias dioscorea muaj cov txiaj ntsig ntawm kev tshem tawm phlegm, zom zaub mov thiab diluting dej, so cov leeg thiab ua kom cov ntshav ncig, thiab txiav tawm malaria. Kev tshawb fawb tshuaj niaj hnub no qhia tau hais tias diosgenin muaj ntau yam tshuaj siv tshuaj, tshwj xeeb tshaj yog nws cov nyhuv tiv thaiv qog.
Flow chart ntawm ob qhov chaw
Yam Source:
Yam (Dioscorea opposita Thunb), tuber ntawm tsev neeg dioscorea, tuaj yeem siv ua zaub mov noj thiab tshuaj tonic. Vim hais tias nws yog nplua nuj nyob rau hauv hmoov txhuv nplej siab, protein, rog, inorganic ntsev, vitamins thiab lwm yam as-ham, tab sis kuj muaj ntau ntawm cellulose thiab choline, saponin, arginine, mannan, polyphenol oxidase thiab lwm yam active cov khoom xyaw, yog li ntawd, yam muaj kev txawj ntse thiab lub hlwb. , txo cov ntshav qab zib, plab hnyuv, raws plab, hnoos thiab expectorant thiab lwm yam dej num thiab yog dav siv nyob rau hauv nourishing zog thiab tiv thaiv thiab tswj ntau yam kab mob. Diosgenin (Diosgenin) yog dav nyob rau hauv Dioscorea, Liliaceae, legumes thiab lwm yam nroj tsuag, uas yog nplua nuj nyob rau hauv Dioscorea nroj tsuag, xws li Dioscorea, Yams, Dioscorea.
Txheej txheem:
. Cov khoom xyaw: Xaiv cov tshiab yam, tev, hlais los yog tsuav.
Enzymatic hydrolysis: Muab cov yam rau hauv cov tshuaj tiv thaiv tank nrog enzyme kua, tswj qhov kub ntawm li 50 degree, enzymatic hydrolysis rau 4 teev. Cov khoom tseem ceeb ntawm cov tshuaj enzyme yog cellulase thiab amylase, uas tuaj yeem decompose cellulose thiab starch nyob rau hauv lub yam thiab tso tawm diosgenin.
Kev sib cais: Ntxiv cov tshuaj enzymolysis rau cov dej nag los nrog thaj tsam 3 npaug ntawm qhov loj ntawm cov tshuaj tiv thaiv tank. Tswj qhov kub ntawm li 70 degree, ntxiv ib qho tsim nyog cov tshuaj cawv, ua ke nrog diosgenin, precipitate rau hauv cov khoom siv.
Ntxuav: Ntxuav cov khoom siv nrog 95% ethanol thiab ntxuav cov impurities hauv ethanol.
Decolorization: Siv txoj kev ua kom carbon decolorization, tshem tawm cov diosgenin hauv cov pa roj carbon activated thaum nws ua ke nrog diosgenin Thaum ua ke, cov saponin adsorbs xim thiab lwm yam impurities tam sim ntawd.
Concentrate: Lub diosgenin ncua kev kawm ntawv yog ntxiv rau lub evaporator, uas yog rhuab thiab nqus los ntawm lub evaporator, kom cov dej nyob rau hauv lub ncua kev kawm ntawv maj evaporates, thiab cov concentration ntawm diosgenin maj mam nce.
Qhuav: Qhuav lub diosgenin mloog zoo los ntawm lub tshuab ziab khaub ncaws rau hauv cov hmoov.
Turmeric Source:
Turmeric, tseem hu ua Ginger, yog ib qho ntawm cov nroj tsuag, qhiav hauv paus txiv hmab txiv ntoo tuaj yeem siv ncaj qha los ua tshuaj, nrog dampness, kub, detoxification los. Ginger paus muaj diosgenin thiab lwm yam, uas yog siv los ua raw khoom ntawm cov tshuaj hormones. Ginger yog ib qho zoo tagnrho thiab tseem ceeb raw khoom rau extracting steroid hormones saponins (feem ntau hu ua saponins). Los ntawm kev hloov kho nws cov steroid structural compounds, ntau yam tshuaj steroid tuaj yeem tau txais. Thawj cov khoom uas tau muab rho tawm los ntawm cov hauv paus ntawm Ginger yog saponone, progesterone acetate (monolipid), prednisone, cortisone series, oxytocin, tshuaj tiv thaiv kab mob thiab lwm yam tshuaj los yog tshuaj. Saponin extraction pov tseg kua tuaj yeem tshem tawm cov qoob loo nucleic acid, yog ib hom zoo chiv. Rhizomes kuj tau siv dav hauv tshuaj, khoom noj, tshuaj pleev ib ce qib siab, tshuaj kho tsiaj thiab lwm yam lag luam. Piv txwv li, lub rhizome yog siv ncaj qha los ua tshuaj, uas muaj cov nyhuv ntawm kev tshem tawm dampness, tshem tawm cov cua sov thiab detoxifying. Dioscorea zingiberensis tuber muaj txiaj ntsig zoo tshuaj thiab tshuaj. Tom qab ua tiav, nws tuaj yeem muab rho tawm mus rau hauv steroids, bisporine thiab lwm yam khoom siv tshuaj thiab tshuaj. Nws yog ib qho tseem ceeb ntawm cov tshuaj hormones. Nws yog lub npe hu ua "niam ntawm cov tshuaj hormones" thiab yog siv dav hauv tshuaj pleev ib ce thiab kev kho mob. Siv rau kev tiv thaiv kab mob, tshuaj loog, tshuaj loog thiab lwm yam tshuaj, yog ib qho kev lag luam ruaj khov rau cov khoom siv tshuaj.
Txheej txheem:
Extraction ntawm diosgenin los ntawm qhiav
Raw khoom: daj Ginger hmoov
Reagent: 70% ethanol
Cov cuab yeej: Ob 250ml beakers, spectrophotometer
(1) Ua kom raug hnyav 10g daj Ginger qauv hauv 250ML huv thiab qhuav beaker, ntxiv 100ML70% ethanol, inUltrasound tau ua ntawm 25.8KHz rau 40min.
(2) Tshem tawm cov lim seem hauv cov tshuaj nrog lub tshuab nqus tsev twj, thiab ncuav lub lim rau hauv 250ml beaker A
(3) Siv lub khob qhuav B thiab ntxiv cov roj (cholesterol) kom tsim nyog (sau cov roj cholesterol) raws li qhov kev txiav txim tau txais hauv 2.3.1. Ntxiv 95% ethanol thiab yaj cov roj cholesterol hauv 80 degree dej da dej kom ncav cuag saturation
(4) Ntxiv cov tshuaj los ntawm A rau B
Muaj nuj nqi:
Dioscin muaj zog pharmacological zog
Nws muaj anti-tumor, anti-thrombotic, anti-allergic, anti-viral thiab anti-shock los. Nws muaj cov tshuaj tiv thaiv kab mob, tiv thaiv kab mob, txo cov roj cholesterol, txo cov ntshav siab, mollusc-tua, thiab tiv thaiv kev xeeb tub.
Cov ntsiav tshuaj Dioscin feem ntau yog siv los kho cov kab mob plawv
Xws li coronary atherosclerosis, coronary insufficiency cov tsos mob, tab sis kuj siv tau los kho angina pectoris, kab mob plawv, triglycerides siab, ntshav siab, roj cholesterol thiab lwm yam kab mob. Nws kuj muaj cov txiaj ntsig ntawm kev tswj cov ntshav lipid hauv cov kab mob raum ntev. Nws txo cov oxidative kev nyuaj siab teb ntawm tus kab mob thiab muaj kev nyab xeeb.
Nws kuj tseem siv tau los kho tracheitis. Nws muaj cov nyhuv tua kab thiab tiv thaiv cov kab mob xws li Trichophyton mentagrophytes.
Lub peroxidase decomposing enzyme muaj nyob rau hauv nws muaj cuab kev tiv thaiv kev laus. Kev siv sijhawm ntev tuaj yeem tshem tawm cov caws pliav ntawm lub ntsej muag thiab ua rau cov tawv nqaij mos thiab du. Nws tuaj yeem siv los ua cov khoom siv raw rau kev sib txuas cov tshuaj steroid thiab cov tshuaj tiv thaiv kab mob.
Daim ntawv thov:
Anticancer mechanism
Cov kev tshawb fawb tshawb fawb tau pom tias dioscin tuaj yeem koom nrog ntau yam kev lom neeg xws li cov txheej txheem ntawm tes, cov txheej txheem metabolic, kev tswj kev lom neeg, cov lus teb kev ntxhov siab, qhia txoj hauv kev thiab kev loj hlob ntawm tes, kom dioscin tuaj yeem cuam tshuam rau hauv cov txheej txheem ntawm lub neej ntawm cov qog nqaij hlav kom ua tiav cov txiaj ntsig tiv thaiv qog noj ntshav. . Cov kev tshawb fawb tau lees paub tias diosgenin tuaj yeem ua rau cov qog cell sib txawv thiab apoptosis, txhim kho cov qog nqaij hlav qog, tswj lub voj voog ntawm tes, thiab inhibit qog cell division thiab proliferation los tiv thaiv qog. Cov tshuaj tiv thaiv kabmob kheesxaws ntawm diosgenin muaj ntau yam teebmeem, thiab txhua qhov sib txuas zoo sib xws. Tam sim no, kev tshawb fawb ntawm nws txoj kev tiv thaiv kab mob qog noj ntshav tsis tau qhia meej txaus, tab sis nrog rau kev tshawb fawb ntxiv ntawm molecular biology, kev nkag siab ntawm cov txheej txheem no yuav muaj ntau dua thiab meej yav tom ntej. Diosgenin yog ib qho tshuaj zoo heev, thiab nws cov khoom siv hydrolyzed diosgenin kuj yog cov khoom siv hluavtaws tseem ceeb rau ntau cov tshuaj steroid. Ntxiv nrog rau cov tshuaj tiv thaiv kab mob qog noj ntshav thiab qee yam kev ua haujlwm lom neeg, diosgenin kuj tseem muaj txiaj ntsig los kho daim siab fibrosis. Cov haujlwm no ua pov thawj tias diosgenin muaj kev tshawb fawb dav dav. Nrog rau kev tshawb fawb tob zuj zus, cov tshuaj muaj txiaj ntsig ntawm diosgenin yuav maj mam tsim, uas qhia txog qhov zoo ntawm daim ntawv thov.
Daim ntawv thov hauv kev npaj tshuaj hepatoprotective
Lub invention nthuav tawm daim ntawv thov ntawm diosgenin hauv kev npaj cov tshuaj tiv thaiv lub siab, uas tuaj yeem cuam tshuam qhov nce ntawm transaminase thiab lactate dehydrogenase kev ua ub no los ntawm cov tshuaj (carbon tetrachloride lossis paracetamol) thiab cawv, txo lub siab Performance index, thiab siv nws lub siab tiv thaiv. Cov nyhuv; tam sim no invention kuj tseem tuaj yeem ua rau SOD kev ua si thiab txo MDA cov ntsiab lus, nce cov ntsiab lus ntawm GSH, suppress lub siab lipid peroxidation uas cov tshuaj (carbon tetrachloride los yog paracetamol) induces; Tib lub sijhawm, qhov kev tsim kho tam sim no tuaj yeem txo TG thiab TC cov ntsiab lus, inhibit Hepatic steatosis los ntawm cawv. Dioscin tuaj yeem siv los ua cov khoom siv raw, thiab ntau hom tshuaj tuaj yeem ua rau ntau hom tshuaj rau kev kho mob raws li cov kev xav tau ntawm cov chaw muag tshuaj thiab cov kev xav tau kho mob, xws li: ntsiav tshuaj, tshuaj ntsiav, tshuaj, tshuaj kua hauv qhov ncauj, granules, thiab lwm yam. , uas muaj kev nyab xeeb (tsis muaj tshuaj lom thiab tsis muaj kev phiv), kev yooj yim, kev lag luam thiab lwm yam zoo.
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